Discovery and initial structure-activity relationships of N-benzyl tricyclic indolines as antibacterials for methicillin-resistant Staphylococcus aureus

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent drug resistant bacteria. In 2012, over 11,000 fatalities in the United States were directly attributable to MRSA. In an effort to develop novel structural and mechanistic classes of antibacterial agents to fight against...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2014-12, Vol.24 (24), p.5602-5605
Hauptverfasser:	Michael Barbour, P, Podoll, Jessica D, Marholz, Laura J, Wang, Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology beta-Lactam Resistance - drug effects Drug Evaluation, Preclinical Indoles - chemical synthesis Indoles - chemistry Indoles - pharmacology Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Polycyclic Compounds - chemistry Staphylococcus aureus Staphylococcus aureus - drug effects Structure-Activity Relationship
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