Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

Key Points Mitochondria are essential for neuronal function and survival. Mitochondria are commonly found in synaptic terminals, where they help to maintain neurotransmission by producing ATP and buffering Ca 2+ . Mitochondrial transport and distribution in neurons is efficiently regulated in respon...

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Veröffentlicht in:	Nature reviews. Neuroscience 2012-02, Vol.13 (2), p.77-93
Hauptverfasser:	Sheng, Zu-Hang, Cai, Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689/364 631/443/319/1557 631/80/642/333 87 Animal Genetics and Genomics Animals Behavioral Sciences Biological and medical sciences Biological Techniques Biological transport Biological Transport - physiology Biomedical and Life Sciences Biomedicine Calcium - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Homeostasis Homeostasis - physiology Humans Medical sciences Metabolism Mitochondria Mitochondria - physiology Models, Neurological Neurobiology Neurodegeneration Neurodegenerative Diseases - etiology Neurodegenerative Diseases - pathology Neurological disorders Neurology Neurons Neurons - pathology Neurons - ultrastructure Neurosciences Pathogenesis Physiological aspects Physiology Proteins review-article Synapses - pathology Synapses - physiology Vertebrates: nervous system and sense organs
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