A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions

STIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum (ER). The series of molecular rearran...

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Veröffentlicht in:	Scientific reports 2016-07, Vol.6 (1), p.29634-29634, Article 29634
Hauptverfasser:	Pacheco, Jonathan, Dominguez, Laura, Bohórquez-Hernández, A., Asanov, Alexander, Vaca, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/287 631/80 82/29 96/35 96/95 Binding Sites Calcium - metabolism Cell Membrane - metabolism Cholesterol - metabolism HEK293 Cells Humanities and Social Sciences Humans Models, Molecular Molecular Dynamics Simulation multidisciplinary Neoplasm Proteins - chemistry Neoplasm Proteins - metabolism ORAI1 Protein - metabolism Phosphatidylinositol 4,5-Diphosphate - metabolism Protein Binding Science Stromal Interaction Molecule 1 - chemistry Stromal Interaction Molecule 1 - metabolism
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