Chronic UVB-irradiation actuates perpetuated dermal matrix remodeling in female mice: Protective role of estrogen
Chronic UVB-exposure and declined estradiol production after menopause represent important factors leading to extrinsic and intrinsic aging, respectively. Remodeling of the extracellular matrix (ECM) plays a crucial role in both responses. Whether the dermal ECM is able to recover after cessation of...
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| Veröffentlicht in: | Scientific reports 2016-07, Vol.6 (1), p.30482-30482, Article 30482 |
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| description | Chronic UVB-exposure and declined estradiol production after menopause represent important factors leading to extrinsic and intrinsic aging, respectively. Remodeling of the extracellular matrix (ECM) plays a crucial role in both responses. Whether the dermal ECM is able to recover after cessation of UVB-irradiation in dependence of estradiol is not known, however of relevance when regarding possible treatment options. Therefore, the endogenous sex hormone production was depleted by ovariectomy in female mice. Half of the mice received estradiol substitution. Mice were UVB-irradiated for 20 weeks and afterwards kept for 10 weeks without irradiation. The collagen-, hyaluronan- and proteoglycan- (versican, biglycan, lumican) matrix, collagen cleavage products and functional skin parameters were analyzed. The intrinsic aging process was characterized by increased collagen fragmentation and accumulation of biglycan. Chronic UVB-irradiation additionally augmented the lumican, versican and hyaluronan content of the dermis. In the absence of further UVB-irradiation the degradation of collagen and accumulation of biglycan in the extrinsically aged group was perpetuated in an excessive matter. Whereas estradiol increased the proteoglycan content, it reversed the effects of the perpetuated extrinsic response on collagen degradation. Suspension of the intrinsic pathway might therefore be sufficient to antagonize UVB-evoked long-term damage to the dermal ECM. |
| doi_str_mv | 10.1038/srep30482 |
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Remodeling of the extracellular matrix (ECM) plays a crucial role in both responses. Whether the dermal ECM is able to recover after cessation of UVB-irradiation in dependence of estradiol is not known, however of relevance when regarding possible treatment options. Therefore, the endogenous sex hormone production was depleted by ovariectomy in female mice. Half of the mice received estradiol substitution. Mice were UVB-irradiated for 20 weeks and afterwards kept for 10 weeks without irradiation. The collagen-, hyaluronan- and proteoglycan- (versican, biglycan, lumican) matrix, collagen cleavage products and functional skin parameters were analyzed. The intrinsic aging process was characterized by increased collagen fragmentation and accumulation of biglycan. Chronic UVB-irradiation additionally augmented the lumican, versican and hyaluronan content of the dermis. In the absence of further UVB-irradiation the degradation of collagen and accumulation of biglycan in the extrinsically aged group was perpetuated in an excessive matter. Whereas estradiol increased the proteoglycan content, it reversed the effects of the perpetuated extrinsic response on collagen degradation. Suspension of the intrinsic pathway might therefore be sufficient to antagonize UVB-evoked long-term damage to the dermal ECM.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep30482</identifier><identifier>PMID: 27460287</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/80 ; 692/420 ; 82/1 ; 82/51 ; Animals ; Biopsy ; Cell Proliferation - drug effects ; Collagen - metabolism ; Dermis - drug effects ; Dermis - metabolism ; Dermis - pathology ; Dermis - radiation effects ; Estrogens - pharmacology ; Female ; Humanities and Social Sciences ; Hyaluronic Acid - metabolism ; Inflammation - pathology ; Mice, Hairless ; multidisciplinary ; Ovariectomy ; Protective Agents - pharmacology ; Proteoglycans - metabolism ; Science ; Ultraviolet Rays ; Up-Regulation - drug effects</subject><ispartof>Scientific reports, 2016-07, Vol.6 (1), p.30482-30482, Article 30482</ispartof><rights>The Author(s) 2016</rights><rights>Copyright © 2016, The Author(s) 2016 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-de7cc726719d4e68f046280e3a6e14307d1a20ddcf7e762f0c580661875bc4433</citedby><cites>FETCH-LOGICAL-c410t-de7cc726719d4e68f046280e3a6e14307d1a20ddcf7e762f0c580661875bc4433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962040/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962040/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27460287$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Röck, Katharina</creatorcontrib><creatorcontrib>Joosse, Simon Andreas</creatorcontrib><creatorcontrib>Müller, Julia</creatorcontrib><creatorcontrib>Heinisch, Nina</creatorcontrib><creatorcontrib>Fuchs, Nicola</creatorcontrib><creatorcontrib>Meusch, Michael</creatorcontrib><creatorcontrib>Zipper, Petra</creatorcontrib><creatorcontrib>Reifenberger, Julia</creatorcontrib><creatorcontrib>Pantel, Klaus</creatorcontrib><creatorcontrib>Fischer, Jens Walter</creatorcontrib><title>Chronic UVB-irradiation actuates perpetuated dermal matrix remodeling in female mice: Protective role of estrogen</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Chronic UVB-exposure and declined estradiol production after menopause represent important factors leading to extrinsic and intrinsic aging, respectively. Remodeling of the extracellular matrix (ECM) plays a crucial role in both responses. Whether the dermal ECM is able to recover after cessation of UVB-irradiation in dependence of estradiol is not known, however of relevance when regarding possible treatment options. Therefore, the endogenous sex hormone production was depleted by ovariectomy in female mice. Half of the mice received estradiol substitution. Mice were UVB-irradiated for 20 weeks and afterwards kept for 10 weeks without irradiation. The collagen-, hyaluronan- and proteoglycan- (versican, biglycan, lumican) matrix, collagen cleavage products and functional skin parameters were analyzed. The intrinsic aging process was characterized by increased collagen fragmentation and accumulation of biglycan. Chronic UVB-irradiation additionally augmented the lumican, versican and hyaluronan content of the dermis. In the absence of further UVB-irradiation the degradation of collagen and accumulation of biglycan in the extrinsically aged group was perpetuated in an excessive matter. Whereas estradiol increased the proteoglycan content, it reversed the effects of the perpetuated extrinsic response on collagen degradation. Suspension of the intrinsic pathway might therefore be sufficient to antagonize UVB-evoked long-term damage to the dermal ECM.</description><subject>631/80</subject><subject>692/420</subject><subject>82/1</subject><subject>82/51</subject><subject>Animals</subject><subject>Biopsy</subject><subject>Cell Proliferation - drug effects</subject><subject>Collagen - metabolism</subject><subject>Dermis - drug effects</subject><subject>Dermis - metabolism</subject><subject>Dermis - pathology</subject><subject>Dermis - radiation effects</subject><subject>Estrogens - pharmacology</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Hyaluronic Acid - metabolism</subject><subject>Inflammation - pathology</subject><subject>Mice, Hairless</subject><subject>multidisciplinary</subject><subject>Ovariectomy</subject><subject>Protective Agents - pharmacology</subject><subject>Proteoglycans - metabolism</subject><subject>Science</subject><subject>Ultraviolet Rays</subject><subject>Up-Regulation - drug effects</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNptkV1rFTEQhoMottRe-Acklyqs5muTPV4I9eAXFPTCehvSZPY0ZTfZTrJF_73RUw8VnJsZ8j68GeYl5ClnrziTw-uCsEimBvGAHAum-k5IIR7em4_IaSnXrFUvNopvHpMjYZRmYjDH5GZ7hTlFTy--v-siogvR1ZgTdb6urkKhC-ACf-ZAA-DsJjq7ivEHRZhzgCmmHY2JjtAkoHP08IZ-xVzB13gLFHN7zSOFUjHvID0hj0Y3FTi96yfk4sP7b9tP3fmXj5-3Z-edV5zVLoDx3ght-CYo0MPIlBYDA-k0cCWZCdwJFoIfDRgtRub7gWnNB9NfeqWkPCFv977LejlD8JAquskuGGeHP2120f6rpHhld_nWqo1ut2PN4PmdAeabta1v51g8TJNLkNdi-cBML41UoqEv9qjHXFog4-EbzuzvlOwhpcY-u7_XgfybSQNe7oHSpLQDtNd5xdRu9R-3Xxysne8</recordid><startdate>20160727</startdate><enddate>20160727</enddate><creator>Röck, Katharina</creator><creator>Joosse, Simon Andreas</creator><creator>Müller, Julia</creator><creator>Heinisch, Nina</creator><creator>Fuchs, Nicola</creator><creator>Meusch, Michael</creator><creator>Zipper, Petra</creator><creator>Reifenberger, Julia</creator><creator>Pantel, Klaus</creator><creator>Fischer, Jens Walter</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160727</creationdate><title>Chronic UVB-irradiation actuates perpetuated dermal matrix remodeling in female mice: Protective role of estrogen</title><author>Röck, Katharina ; Joosse, Simon Andreas ; Müller, Julia ; Heinisch, Nina ; Fuchs, Nicola ; Meusch, Michael ; Zipper, Petra ; Reifenberger, Julia ; Pantel, Klaus ; Fischer, Jens Walter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-de7cc726719d4e68f046280e3a6e14307d1a20ddcf7e762f0c580661875bc4433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>631/80</topic><topic>692/420</topic><topic>82/1</topic><topic>82/51</topic><topic>Animals</topic><topic>Biopsy</topic><topic>Cell Proliferation - drug effects</topic><topic>Collagen - metabolism</topic><topic>Dermis - drug effects</topic><topic>Dermis - metabolism</topic><topic>Dermis - pathology</topic><topic>Dermis - radiation effects</topic><topic>Estrogens - pharmacology</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Hyaluronic Acid - metabolism</topic><topic>Inflammation - pathology</topic><topic>Mice, Hairless</topic><topic>multidisciplinary</topic><topic>Ovariectomy</topic><topic>Protective Agents - pharmacology</topic><topic>Proteoglycans - metabolism</topic><topic>Science</topic><topic>Ultraviolet Rays</topic><topic>Up-Regulation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Röck, Katharina</creatorcontrib><creatorcontrib>Joosse, Simon Andreas</creatorcontrib><creatorcontrib>Müller, Julia</creatorcontrib><creatorcontrib>Heinisch, Nina</creatorcontrib><creatorcontrib>Fuchs, Nicola</creatorcontrib><creatorcontrib>Meusch, Michael</creatorcontrib><creatorcontrib>Zipper, Petra</creatorcontrib><creatorcontrib>Reifenberger, Julia</creatorcontrib><creatorcontrib>Pantel, Klaus</creatorcontrib><creatorcontrib>Fischer, Jens Walter</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Röck, Katharina</au><au>Joosse, Simon Andreas</au><au>Müller, Julia</au><au>Heinisch, Nina</au><au>Fuchs, Nicola</au><au>Meusch, Michael</au><au>Zipper, Petra</au><au>Reifenberger, Julia</au><au>Pantel, Klaus</au><au>Fischer, Jens Walter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic UVB-irradiation actuates perpetuated dermal matrix remodeling in female mice: Protective role of estrogen</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2016-07-27</date><risdate>2016</risdate><volume>6</volume><issue>1</issue><spage>30482</spage><epage>30482</epage><pages>30482-30482</pages><artnum>30482</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Chronic UVB-exposure and declined estradiol production after menopause represent important factors leading to extrinsic and intrinsic aging, respectively. Remodeling of the extracellular matrix (ECM) plays a crucial role in both responses. Whether the dermal ECM is able to recover after cessation of UVB-irradiation in dependence of estradiol is not known, however of relevance when regarding possible treatment options. Therefore, the endogenous sex hormone production was depleted by ovariectomy in female mice. Half of the mice received estradiol substitution. Mice were UVB-irradiated for 20 weeks and afterwards kept for 10 weeks without irradiation. The collagen-, hyaluronan- and proteoglycan- (versican, biglycan, lumican) matrix, collagen cleavage products and functional skin parameters were analyzed. The intrinsic aging process was characterized by increased collagen fragmentation and accumulation of biglycan. Chronic UVB-irradiation additionally augmented the lumican, versican and hyaluronan content of the dermis. In the absence of further UVB-irradiation the degradation of collagen and accumulation of biglycan in the extrinsically aged group was perpetuated in an excessive matter. Whereas estradiol increased the proteoglycan content, it reversed the effects of the perpetuated extrinsic response on collagen degradation. Suspension of the intrinsic pathway might therefore be sufficient to antagonize UVB-evoked long-term damage to the dermal ECM.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>27460287</pmid><doi>10.1038/srep30482</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/80 692/420 82/1 82/51 Animals Biopsy Cell Proliferation - drug effects Collagen - metabolism Dermis - drug effects Dermis - metabolism Dermis - pathology Dermis - radiation effects Estrogens - pharmacology Female Humanities and Social Sciences Hyaluronic Acid - metabolism Inflammation - pathology Mice, Hairless multidisciplinary Ovariectomy Protective Agents - pharmacology Proteoglycans - metabolism Science Ultraviolet Rays Up-Regulation - drug effects |
| title | Chronic UVB-irradiation actuates perpetuated dermal matrix remodeling in female mice: Protective role of estrogen |
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