Human GBP1 does not localize to pathogen vacuoles but restricts Toxoplasma gondii

Summary Guanylate binding proteins (GBPs) are a family of large interferon‐inducible GTPases that are transcriptionally upregulated upon infection with intracellular pathogens. Murine GBPs (mGBPs) including mGBP1 and 2 localize to and disrupt pathogen‐containing vacuoles (PVs) resulting in the cell‐...

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Veröffentlicht in:	Cellular microbiology 2016-08, Vol.18 (8), p.1056-1064
Hauptverfasser:	Johnston, Ashleigh C., Piro, Anthony, Clough, Barbara, Siew, Malvin, Virreira Winter, Sebastian, Coers, Jörn, Frickel, Eva‐Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Breaking Report Chlamydia trachomatis Chlamydia trachomatis - physiology Epithelial Cells - metabolism Epithelial Cells - microbiology Epithelial Cells - parasitology GTP-Binding Proteins - metabolism Humans Pathogens Protein Transport Salmonella typhimurium Salmonella typhimurium - physiology Toxoplasma - physiology Toxoplasma gondii Vacuoles - metabolism Vacuoles - parasitology
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