Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122

Background and Purpose Signalling through phospholipase C (PLC) controls many cellular processes. Much information on the relevance of this important pathway has been derived from pharmacological inhibition of the enzymatic activity of PLC. We found that the most frequently employed PLC inhibitor, U...

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Veröffentlicht in:	British journal of pharmacology 2016-08, Vol.173 (16), p.2555-2569
Hauptverfasser:	Leitner, Michael G, Michel, Niklas, Behrendt, Marc, Dierich, Marlen, Dembla, Sandeep, Wilke, Bettina U, Konrad, Maik, Lindner, Moritz, Oberwinkler, Johannes, Oliver, Dominik
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium ions Cell lines Cells, Cultured Dose-Response Relationship, Drug Enzymatic activity Estrenes - administration & dosage Estrenes - pharmacology HEK293 Cells Humans Information processing Ion channels Molecular Structure Phospholipase Phospholipase C Pyrrolidinones - administration & dosage Pyrrolidinones - pharmacology Research Paper Research Papers Second messengers Signal transduction Structure-Activity Relationship Transient receptor potential proteins TRPM Cation Channels - agonists TRPM Cation Channels - metabolism Type C Phospholipases - antagonists & inhibitors Type C Phospholipases - metabolism
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