TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis

Blood flow–induced shear stress controls endothelial cell (EC) physiology during atherosclerosis via transcriptional mechanisms that are incompletely understood. The mechanosensitive transcription factor TWIST is expressed during embryogenesis, but its role in EC responses to shear stress and focal...

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Veröffentlicht in:	Circulation research 2016-07, Vol.119 (3), p.450-462
Hauptverfasser:	Mahmoud, Marwa M., Kim, Hyejeong Rosemary, Xing, Rouyu, Hsiao, Sarah, Mammoto, Akiko, Chen, Jing, Serbanovic-Canic, Jovana, Feng, Shuang, Bowden, Neil P., Maguire, Richard, Ariaans, Markus, Francis, Sheila E., Weinberg, Peter D., van der Heiden, Kim, Jones, Elizabeth A., Chico, Timothy J.A., Ridger, Victoria, Evans, Paul C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis - metabolism Atherosclerosis - pathology Blood Flow Velocity - physiology Cell Movement - physiology Cell Proliferation - physiology Cells, Cultured Cellular Biology Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - pathology Humans Male Mice Mice, Knockout Mice, Transgenic Nuclear Proteins - biosynthesis Swine Twist-Related Protein 1 - biosynthesis Zebrafish
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