Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

The bromodomain and extraterminal (BET) inhibitor JQ1 synergizes with the histone deacetylase inhibitor SAHA to suppress tumor growth in mouse models of pancreatic cancer. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers and shows resistance to any therapeutic strategy...

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Veröffentlicht in:	Nature medicine 2015-10, Vol.21 (10), p.1163-1171
Hauptverfasser:	Mazur, Pawel K, Herner, Alexander, Mello, Stephano S, Wirth, Matthias, Hausmann, Simone, Sánchez-Rivera, Francisco J, Lofgren, Shane M, Kuschma, Timo, Hahn, Stephan A, Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noël, Peter B, Braren, Rickmer, Erkan, Mert, Kleeff, Jörg, Sipos, Bence, Sayles, Leanne C, Heikenwalder, Mathias, Heßmann, Elisabeth, Ellenrieder, Volker, Esposito, Irene, Jacks, Tyler, Bradner, James E, Khatri, Purvesh, Sweet-Cordero, E Alejandro, Attardi, Laura D, Schmid, Roland M, Schneider, Guenter, Sage, Julien, Siveke, Jens T
Format:	Artikel
Sprache:	eng
Schlagworte:	13 59/57 631/1647/767/70 631/67/1504/1713 64/110 692/308/575 82/1 82/51 96/106 96/2 96/95 Adenocarcinoma Adenocarcinoma - drug therapy Adenocarcinoma - therapy Animal models Animals Biomedicine Cancer Cancer Research Cancer therapies Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - therapy Care and treatment Cell death Chromatin Clinical trials Clustered Regularly Interspaced Short Palindromic Repeats CRISPR Epigenesis, Genetic Epigenetics Genetic modification Genome editing Histone deacetylase Histone Deacetylase Inhibitors - therapeutic use Histones Humans Infectious Diseases Inflammation Inhibitors Metabolic Diseases Mice Molecular Medicine Mortality Myc protein Neurosciences Pancreatic cancer Pharmacology Physiological aspects Proteins Proteins - antagonists & inhibitors Tumors
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