Do all β-blockers attenuate the excess hematopoietic progenitor cell mobilization from the bone marrow following trauma/hemorrhagic shock?

Severe injury results in increased mobilization of hematopoietic progenitor cells (HPC) from the bone marrow (BM) to sites of injury, which may contribute to persistent BM dysfunction after trauma. Norepinephrine is a known inducer of HPC mobilization, and nonselective β-blockade with propranolol ha...

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Veröffentlicht in:	The journal of trauma and acute care surgery 2014-04, Vol.76 (4), p.970-975
Hauptverfasser:	Pasupuleti, Latha V, Cook, Kristin M, Sifri, Ziad C, Alzate, Walter D, Livingston, David H, Mohr, Alicia M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Cell Movement - drug effects Cells, Cultured Disease Models, Animal Flow Cytometry Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Male Rats Rats, Sprague-Dawley Shock, Hemorrhagic - drug therapy Shock, Hemorrhagic - pathology
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