Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease

The autophagy pathway has been recognized as a mechanism of survival and therapy resistance in cancer, yet the extent of autophagy's function in metastatic progression is still unclear. Therefore, we used murine models of metastatic cancer to investigate the effect of autophagy modulation on me...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2016-08, Vol.358 (2), p.282-293
Hauptverfasser:	Barnard, Rebecca A, Regan, Daniel P, Hansen, Ryan J, Maycotte, Paola, Thorburn, Andrew, Gustafson, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects Autophagy - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cellular and Molecular Chloroquine - pharmacology Cisplatin - pharmacology Drug Synergism Female Mice Neoadjuvant Therapy Neoplasm Metastasis Neoplasm Staging Time Factors Trehalose - pharmacology
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