A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex
The zebrafish pineal complex consists of four cell types (rod and cone photoreceptors, projection neurons and parapineal neurons) that are derived from a single pineal complex anlage. After specification, parapineal neurons migrate unilaterally away from the rest of the pineal complex whereas rods,...
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| Veröffentlicht in: | Development (Cambridge) 2016-07, Vol.143 (14), p.2641-2650 |
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| creator | Khuansuwan, Sataree Clanton, Joshua A Dean, Benjamin J Patton, James G Gamse, Joshua T |
| description | The zebrafish pineal complex consists of four cell types (rod and cone photoreceptors, projection neurons and parapineal neurons) that are derived from a single pineal complex anlage. After specification, parapineal neurons migrate unilaterally away from the rest of the pineal complex whereas rods, cones and projection neurons are non-migratory. The transcription factor Tbx2b is important for both the correct number and migration of parapineal neurons. We find that two additional transcription factors, Flh and Nr2e3, negatively regulate parapineal formation. Flh induces non-migratory neuron fates and limits the extent of parapineal specification, in part by activation of Nr2e3 expression. Tbx2b is positively regulated by Flh, but opposes Flh action during specification of parapineal neurons. Loss of parapineal neuron specification in Tbx2b-deficient embryos can be partially rescued by loss of Nr2e3 or Flh function; however, parapineal migration absolutely requires Tbx2b activity. We conclude that cell specification and migration in the pineal complex are regulated by a network of at least three transcription factors. |
| doi_str_mv | 10.1242/dev.131680 |
| format | Article |
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After specification, parapineal neurons migrate unilaterally away from the rest of the pineal complex whereas rods, cones and projection neurons are non-migratory. The transcription factor Tbx2b is important for both the correct number and migration of parapineal neurons. We find that two additional transcription factors, Flh and Nr2e3, negatively regulate parapineal formation. Flh induces non-migratory neuron fates and limits the extent of parapineal specification, in part by activation of Nr2e3 expression. Tbx2b is positively regulated by Flh, but opposes Flh action during specification of parapineal neurons. Loss of parapineal neuron specification in Tbx2b-deficient embryos can be partially rescued by loss of Nr2e3 or Flh function; however, parapineal migration absolutely requires Tbx2b activity. We conclude that cell specification and migration in the pineal complex are regulated by a network of at least three transcription factors.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.131680</identifier><identifier>PMID: 27317804</identifier><language>eng</language><publisher>England: The Company of Biologists Ltd</publisher><subject>Animals ; Body Patterning ; Cell Count ; Cell Lineage - genetics ; Cell Movement - genetics ; Danio rerio ; Gene Dosage ; Gene Expression Regulation, Developmental ; Gene Regulatory Networks ; Habenula - embryology ; Habenula - metabolism ; Larva - metabolism ; Mosaicism ; Mutation - genetics ; Neurons - cytology ; Neurons - metabolism ; Pineal Gland - cytology ; Pineal Gland - embryology ; Pineal Gland - innervation ; Pineal Gland - metabolism ; Retinal Rod Photoreceptor Cells - cytology ; Retinal Rod Photoreceptor Cells - metabolism ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Zebrafish - embryology ; Zebrafish - genetics ; Zebrafish Proteins - genetics ; Zebrafish Proteins - metabolism</subject><ispartof>Development (Cambridge), 2016-07, Vol.143 (14), p.2641-2650</ispartof><rights>2016. 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After specification, parapineal neurons migrate unilaterally away from the rest of the pineal complex whereas rods, cones and projection neurons are non-migratory. The transcription factor Tbx2b is important for both the correct number and migration of parapineal neurons. We find that two additional transcription factors, Flh and Nr2e3, negatively regulate parapineal formation. Flh induces non-migratory neuron fates and limits the extent of parapineal specification, in part by activation of Nr2e3 expression. Tbx2b is positively regulated by Flh, but opposes Flh action during specification of parapineal neurons. Loss of parapineal neuron specification in Tbx2b-deficient embryos can be partially rescued by loss of Nr2e3 or Flh function; however, parapineal migration absolutely requires Tbx2b activity. We conclude that cell specification and migration in the pineal complex are regulated by a network of at least three transcription factors.</description><subject>Animals</subject><subject>Body Patterning</subject><subject>Cell Count</subject><subject>Cell Lineage - genetics</subject><subject>Cell Movement - genetics</subject><subject>Danio rerio</subject><subject>Gene Dosage</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Gene Regulatory Networks</subject><subject>Habenula - embryology</subject><subject>Habenula - metabolism</subject><subject>Larva - metabolism</subject><subject>Mosaicism</subject><subject>Mutation - genetics</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>Pineal Gland - cytology</subject><subject>Pineal Gland - embryology</subject><subject>Pineal Gland - innervation</subject><subject>Pineal Gland - metabolism</subject><subject>Retinal Rod Photoreceptor Cells - cytology</subject><subject>Retinal Rod Photoreceptor Cells - metabolism</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Zebrafish - embryology</subject><subject>Zebrafish - genetics</subject><subject>Zebrafish Proteins - genetics</subject><subject>Zebrafish Proteins - metabolism</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9v1DAQxS0EotvChQ-AfERIKR7bieMLUlVBQarEBc7WxJnsGpI42N7lz6cny5YKbpxGM_PT07x5jD0DcQlSy1c9HS5BQdOKB2wD2pjKgrQP2UbYWlRgLZyx85w_CyFUY8xjdiaNAtMKvWHlipeEc_YpLCXEmQ_oS0x8pvItpi_cx7mkOGbuaRz5FLYJf2M49ytaiPfkQ14nmYeZl91xcKAxLmHe8p_UJRxC3vG1JRxXtWkZ6fsT9mjAMdPTu3rBPr198_H6XXX74eb99dVt5TVAqQY9NB57sqb3CFSD7jWqRjbKEtR139Kgte9820mBCrvaKkSUVtaDgdpbdcFen3SXfTdR72n1gqNbUpgw_XARg_t3M4ed28aD07ZulZKrwIs7gRS_7ikXN4V8_ATOFPfZQQvQtlJb8x-oaIRpbA0r-vKE-hRzTjTcXwTCHRN16w_dKdEVfv63h3v0T4TqF9UZn_Y</recordid><startdate>20160715</startdate><enddate>20160715</enddate><creator>Khuansuwan, Sataree</creator><creator>Clanton, Joshua A</creator><creator>Dean, Benjamin J</creator><creator>Patton, James G</creator><creator>Gamse, Joshua T</creator><general>The Company of Biologists Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4888-4768</orcidid><orcidid>https://orcid.org/0000-0001-5749-0870</orcidid></search><sort><creationdate>20160715</creationdate><title>A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex</title><author>Khuansuwan, Sataree ; Clanton, Joshua A ; Dean, Benjamin J ; Patton, James G ; Gamse, Joshua T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-f4f6cade97dca1e514d4a362639e155d8ef44cbc8b20a3ab593aaa2925f715c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Body Patterning</topic><topic>Cell Count</topic><topic>Cell Lineage - genetics</topic><topic>Cell Movement - genetics</topic><topic>Danio rerio</topic><topic>Gene Dosage</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Gene Regulatory Networks</topic><topic>Habenula - embryology</topic><topic>Habenula - metabolism</topic><topic>Larva - metabolism</topic><topic>Mosaicism</topic><topic>Mutation - genetics</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>Pineal Gland - cytology</topic><topic>Pineal Gland - embryology</topic><topic>Pineal Gland - innervation</topic><topic>Pineal Gland - metabolism</topic><topic>Retinal Rod Photoreceptor Cells - cytology</topic><topic>Retinal Rod Photoreceptor Cells - metabolism</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Zebrafish - embryology</topic><topic>Zebrafish - genetics</topic><topic>Zebrafish Proteins - genetics</topic><topic>Zebrafish Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khuansuwan, Sataree</creatorcontrib><creatorcontrib>Clanton, Joshua A</creatorcontrib><creatorcontrib>Dean, Benjamin J</creatorcontrib><creatorcontrib>Patton, James G</creatorcontrib><creatorcontrib>Gamse, Joshua T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khuansuwan, Sataree</au><au>Clanton, Joshua A</au><au>Dean, Benjamin J</au><au>Patton, James G</au><au>Gamse, Joshua T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2016-07-15</date><risdate>2016</risdate><volume>143</volume><issue>14</issue><spage>2641</spage><epage>2650</epage><pages>2641-2650</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>The zebrafish pineal complex consists of four cell types (rod and cone photoreceptors, projection neurons and parapineal neurons) that are derived from a single pineal complex anlage. After specification, parapineal neurons migrate unilaterally away from the rest of the pineal complex whereas rods, cones and projection neurons are non-migratory. The transcription factor Tbx2b is important for both the correct number and migration of parapineal neurons. We find that two additional transcription factors, Flh and Nr2e3, negatively regulate parapineal formation. Flh induces non-migratory neuron fates and limits the extent of parapineal specification, in part by activation of Nr2e3 expression. Tbx2b is positively regulated by Flh, but opposes Flh action during specification of parapineal neurons. Loss of parapineal neuron specification in Tbx2b-deficient embryos can be partially rescued by loss of Nr2e3 or Flh function; however, parapineal migration absolutely requires Tbx2b activity. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Body Patterning Cell Count Cell Lineage - genetics Cell Movement - genetics Danio rerio Gene Dosage Gene Expression Regulation, Developmental Gene Regulatory Networks Habenula - embryology Habenula - metabolism Larva - metabolism Mosaicism Mutation - genetics Neurons - cytology Neurons - metabolism Pineal Gland - cytology Pineal Gland - embryology Pineal Gland - innervation Pineal Gland - metabolism Retinal Rod Photoreceptor Cells - cytology Retinal Rod Photoreceptor Cells - metabolism Transcription Factors - genetics Transcription Factors - metabolism Zebrafish - embryology Zebrafish - genetics Zebrafish Proteins - genetics Zebrafish Proteins - metabolism |
| title | A transcription factor network controls cell migration and fate decisions in the developing zebrafish pineal complex |
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