Adenomatous polyposis coli regulates radial axonal sorting and myelination in the PNS

The tumor suppressor protein adenomatous polyposis coli (APC) is multifunctional - it participates in the canonical Wnt/β-catenin signal transduction pathway as well as modulating cytoskeleton function. Although APC is expressed by Schwann cells, the role that it plays in these cells and in the myel...

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Veröffentlicht in:	Development (Cambridge) 2016-07, Vol.143 (13), p.2356-2366
Hauptverfasser:	Elbaz, Benayahu, Traka, Maria, Kunjamma, Rejani B, Dukala, Danuta, Brosius Lutz, Amanda, Anton, E S, Barres, Ben A, Soliven, Betty, Popko, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli Protein - metabolism Animals Axons - metabolism Cell Differentiation - genetics Hindlimb - pathology Integrases - metabolism Mice Myelin Sheath - metabolism Peripheral Nervous System - metabolism Pseudopodia - metabolism Schwann Cells - cytology Schwann Cells - metabolism Sciatic Nerve - metabolism Wnt Signaling Pathway - genetics
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