Targeting the Cytochrome bc1 Complex of Leishmania Parasites for Discovery of Novel Drugs

Endochin-like quinolones (ELQs) are potent and specific inhibitors of cytochrome bc1 from Plasmodium falciparum and Toxoplasma gondii and show promise for novel antiparasitic drug development. To determine whether the mitochondrial electron transport chain of Leishmania parasites could be targeted s...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2016-08, Vol.60 (8), p.4972-4982
Hauptverfasser:	Ortiz, Diana, Forquer, Isaac, Boitz, Jan, Soysa, Radika, Elya, Carolyn, Fulwiler, Audrey, Nilsen, Aaron, Polley, Tamsen, Riscoe, Michael K, Ullman, Buddy, Landfear, Scott M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Antiprotozoal Agents Antiprotozoal Agents - pharmacology Cell Line Electron Transport Complex III Electron Transport Complex III - antagonists & inhibitors Electron Transport Complex III - metabolism Experimental Therapeutics Inhibitory Concentration 50 Leishmania Leishmania - drug effects Leishmania donovani - drug effects Leishmania donovani - metabolism Leishmania mexicana Leishmania mexicana - drug effects Leishmania mexicana - metabolism Membrane Potential, Mitochondrial - drug effects Mice NAD - metabolism Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - metabolism Quinolones Quinolones - pharmacology Reactive Oxygen Species - metabolism Toxoplasma gondii
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