Influence of Renal Replacement Modalities on Amikacin Population Pharmacokinetics in Critically Ill Patients on Continuous Renal Replacement Therapy

The objective of this study was to describe amikacin pharmacokinetics (PK) in critically ill patients receiving equal doses (30 ml/kg of body weight/h) of continuous venovenous hemofiltration (CVVH) and continuous venovenous hemodiafiltration (CVVHDF). Patients receiving amikacin and undergoing CVVH...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2016-08, Vol.60 (8), p.4901-4909
Hauptverfasser:	Roger, Claire, Wallis, Steven C, Muller, Laurent, Saissi, Gilbert, Lipman, Jeffrey, Lefrant, Jean-Yves, Roberts, Jason A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amikacin Amikacin - pharmacokinetics Amikacin - therapeutic use Anti-Bacterial Agents Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Critical Illness Female Hemodiafiltration - methods Hemofiltration - methods Humans Kidney - metabolism Life Sciences Male Metabolic Clearance Rate - drug effects Microbiology and Parasitology Monte Carlo Method Pharmaceutical sciences Pharmacology Renal Replacement Therapy - methods
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