Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy

MicroRNAs (miRNAs) have been extensively examined in pathological cardiac hypertrophy. However, few studies focused on profiling the miRNA alterations in physiological hypertrophic hearts. In this study we generated a transgenic mouse model with cardiac-specific overexpression of miR-223. Our result...

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Veröffentlicht in:	The Journal of biological chemistry 2016-07, Vol.291 (30), p.15700-15713
Hauptverfasser:	Yang, Liwang, Li, Yutian, Wang, Xiaohong, Mu, Xingjiang, Qin, Dongze, Huang, Wei, Alshahrani, Saeed, Nieman, Michelle, Peng, Jiangtong, Essandoh, Kobina, Peng, Tianqing, Wang, Yigang, Lorenz, John, Soleimani, Manoocher, Zhao, Zhi-Qing, Fan, Guo-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Receptors, Type II - genetics Activin Receptors, Type II - metabolism Adenoviridae Akt PKB Animals cardiac hypertrophy Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - pathology cardiomyocyte Disease Models, Animal F-Box Proteins - genetics F-Box Proteins - metabolism F-Box-WD Repeat-Containing Protein 7 Gene Expression Regulation Mice Mice, Transgenic microRNA (miRNA) MicroRNAs - biosynthesis MicroRNAs - genetics Molecular Bases of Disease Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Signal Transduction Transduction, Genetic transgenic mice Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism
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