The Interaction between Cancer Stem Cell Marker CD133 and Src Protein Promotes Focal Adhesion Kinase (FAK) Phosphorylation and Cell Migration

CD133, a widely known cancer stem cell marker, has been proved to promote tumor metastasis. However, the mechanism by which CD133 regulates metastasis remains largely unknown. Here, we report that CD133 knockdown inhibits cancer cell migration, and CD133 overexpression promotes cell migration. CD133...

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Veröffentlicht in:	The Journal of biological chemistry 2016-07, Vol.291 (30), p.15540-15550
Hauptverfasser:	Liu, Chanjuan, Li, Yinan, Xing, Yang, Cao, Benjin, Yang, Fan, Yang, Tianxiao, Ai, Zhilong, Wei, Yuanyan, Jiang, Jianhai
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen - genetics AC133 Antigen - metabolism CD133 Cell Line, Tumor Cell Movement focal adhesion kinase (FAK) Focal Adhesion Kinase 1 - genetics Focal Adhesion Kinase 1 - metabolism Humans migration Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Phosphorylation Protein Phosphatase 2 - genetics Protein Phosphatase 2 - metabolism protein phosphorylation protein-protein interaction protein-tyrosine kinase 2 (PTK2) Proto-Oncogene Proteins pp60(c-src) - genetics Proto-Oncogene Proteins pp60(c-src) - metabolism Signal Transduction Src
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