Associations of high HDL cholesterol level with all-cause mortality in patients with heart failure complicating coronary heart disease
The aim of the present study was to evaluate the association between HDL cholesterol level and all-cause mortality in patients with ejection fraction reduced heart failure (EFrHF) complicating coronary heart disease (CHD).A total of 323 patients were retrospectively recruited. Patients were divided...
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| Veröffentlicht in: | Medicine (Baltimore) 2016-07, Vol.95 (28), p.e3974-e3974 |
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| creator | Cai, Anping Li, Xida Zhong, Qi Li, Minming Wang, Rui Liang, Yingcong Chen, Wenzhong Huang, Tehui Li, Xiaohong Zhou, Yingling Li, Liwen |
| description | The aim of the present study was to evaluate the association between HDL cholesterol level and all-cause mortality in patients with ejection fraction reduced heart failure (EFrHF) complicating coronary heart disease (CHD).A total of 323 patients were retrospectively recruited. Patients were divided into low and high HDL cholesterol groups. Between-group differences and associations between HDL cholesterol level and all-cause mortality were assessed.Patients in the high HDL cholesterol group had higher HDL cholesterol level and other lipid components (P |
| doi_str_mv | 10.1097/MD.0000000000003974 |
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Patients were divided into low and high HDL cholesterol groups. Between-group differences and associations between HDL cholesterol level and all-cause mortality were assessed.Patients in the high HDL cholesterol group had higher HDL cholesterol level and other lipid components (P <0.05 for all comparison). Lower levels of alanine aminotransferase (ALT), high-sensitivity C-reactive protein (Hs-CRP), and higher albumin (ALB) level were observed in the high HDL cholesterol group (P <0.05 for all comparison). Although left ventricular ejection fraction (LVEF) were comparable (28.8 ± 4.5% vs 28.4 ± 4.6%, P = 0.358), mean mortality rate in the high HDL cholesterol group was significantly lower (43.5% vs 59.1%, P = 0.007). HDL cholesterol level was positively correlated with ALB level, while inversely correlated with ALT, Hs-CRP, and NYHA classification. Logistic regression analysis revealed that after extensively adjusted for confounding variates, HDL cholesterol level remained significantly associated with all-cause mortality although the magnitude of association was gradually attenuated with odds ratio of 0.007 (95% confidence interval 0.001-0.327, P = 0.012).Higher HDL cholesterol level is associated with better survival in patients with EFrHF complicating CHD, and future studies are necessary to demonstrate whether increasing HDL cholesterol level will confer survival benefit in these populations of patients.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000003974</identifier><identifier>PMID: 27428188</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>China - epidemiology ; Cholesterol, HDL - blood ; Coronary Artery Disease - blood ; Coronary Artery Disease - complications ; Coronary Artery Disease - mortality ; Female ; Heart Failure - blood ; Heart Failure - etiology ; Heart Failure - mortality ; Humans ; Hypercholesterolemia - blood ; Male ; Middle Aged ; Observational Study ; Retrospective Studies</subject><ispartof>Medicine (Baltimore), 2016-07, Vol.95 (28), p.e3974-e3974</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4500-cc23ea8ccce66155f6385f071e420ed9780dc1ba5268f7d15e25e2dfd8cc07913</citedby><cites>FETCH-LOGICAL-c4500-cc23ea8ccce66155f6385f071e420ed9780dc1ba5268f7d15e25e2dfd8cc07913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956782/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956782/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27428188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Anping</creatorcontrib><creatorcontrib>Li, Xida</creatorcontrib><creatorcontrib>Zhong, Qi</creatorcontrib><creatorcontrib>Li, Minming</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Liang, Yingcong</creatorcontrib><creatorcontrib>Chen, Wenzhong</creatorcontrib><creatorcontrib>Huang, Tehui</creatorcontrib><creatorcontrib>Li, Xiaohong</creatorcontrib><creatorcontrib>Zhou, Yingling</creatorcontrib><creatorcontrib>Li, Liwen</creatorcontrib><title>Associations of high HDL cholesterol level with all-cause mortality in patients with heart failure complicating coronary heart disease</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The aim of the present study was to evaluate the association between HDL cholesterol level and all-cause mortality in patients with ejection fraction reduced heart failure (EFrHF) complicating coronary heart disease (CHD).A total of 323 patients were retrospectively recruited. Patients were divided into low and high HDL cholesterol groups. Between-group differences and associations between HDL cholesterol level and all-cause mortality were assessed.Patients in the high HDL cholesterol group had higher HDL cholesterol level and other lipid components (P <0.05 for all comparison). Lower levels of alanine aminotransferase (ALT), high-sensitivity C-reactive protein (Hs-CRP), and higher albumin (ALB) level were observed in the high HDL cholesterol group (P <0.05 for all comparison). Although left ventricular ejection fraction (LVEF) were comparable (28.8 ± 4.5% vs 28.4 ± 4.6%, P = 0.358), mean mortality rate in the high HDL cholesterol group was significantly lower (43.5% vs 59.1%, P = 0.007). HDL cholesterol level was positively correlated with ALB level, while inversely correlated with ALT, Hs-CRP, and NYHA classification. Logistic regression analysis revealed that after extensively adjusted for confounding variates, HDL cholesterol level remained significantly associated with all-cause mortality although the magnitude of association was gradually attenuated with odds ratio of 0.007 (95% confidence interval 0.001-0.327, P = 0.012).Higher HDL cholesterol level is associated with better survival in patients with EFrHF complicating CHD, and future studies are necessary to demonstrate whether increasing HDL cholesterol level will confer survival benefit in these populations of patients.</description><subject>China - epidemiology</subject><subject>Cholesterol, HDL - blood</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - mortality</subject><subject>Female</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - mortality</subject><subject>Humans</subject><subject>Hypercholesterolemia - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Retrospective Studies</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1u1DAQhS0EokvhCZCQL7lJGTv-SW6Qqm5pkbbiBq4t15lsDE682ElXfQGeG5ddqoJlyfL4O8ejOYS8ZXDGoNUfbtZn8GTVrRbPyIrJWlWyVeI5WQFwWelSPyGvcv4OwGrNxUtywrXgDWuaFfl1nnN03s4-TpnGng5-O9Dr9Ya6IQbMM6YYaMA7DHTv54HaECpnl4x0jGm2wc_31E90VxxwmvMBGtCmmfbWhyUhdXHcBe8KMW3LJcXJpvsj0_mMNuNr8qK3IeOb43lKvn26_HpxXW2-XH2-ON9UTkiAyjleo22cc6gUk7JXdSN70AwFB-xa3UDn2K2VXDW97phEXnbXd0UCumX1Kfl48N0ttyN2rrScbDC75MfSk4nWm39fJj-YbbwzopVKN7wYvD8apPhzKfMxo88OQ7ATxiUb1oDUqmVaFLQ-oC7FnBP2j98wMA8Jmpu1-T_Bonr3tMNHzd_ICiAOwD6Gkk7-EZY9JlPGGebhj5_ULa84MFUGw6EqFQb1b3-1qj8</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Cai, Anping</creator><creator>Li, Xida</creator><creator>Zhong, Qi</creator><creator>Li, Minming</creator><creator>Wang, Rui</creator><creator>Liang, Yingcong</creator><creator>Chen, Wenzhong</creator><creator>Huang, Tehui</creator><creator>Li, Xiaohong</creator><creator>Zhou, Yingling</creator><creator>Li, Liwen</creator><general>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160701</creationdate><title>Associations of high HDL cholesterol level with all-cause mortality in patients with heart failure complicating coronary heart disease</title><author>Cai, Anping ; Li, Xida ; Zhong, Qi ; Li, Minming ; Wang, Rui ; Liang, Yingcong ; Chen, Wenzhong ; Huang, Tehui ; Li, Xiaohong ; Zhou, Yingling ; Li, Liwen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4500-cc23ea8ccce66155f6385f071e420ed9780dc1ba5268f7d15e25e2dfd8cc07913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>China - epidemiology</topic><topic>Cholesterol, HDL - blood</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - mortality</topic><topic>Female</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - mortality</topic><topic>Humans</topic><topic>Hypercholesterolemia - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Anping</creatorcontrib><creatorcontrib>Li, Xida</creatorcontrib><creatorcontrib>Zhong, Qi</creatorcontrib><creatorcontrib>Li, Minming</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><creatorcontrib>Liang, Yingcong</creatorcontrib><creatorcontrib>Chen, Wenzhong</creatorcontrib><creatorcontrib>Huang, Tehui</creatorcontrib><creatorcontrib>Li, Xiaohong</creatorcontrib><creatorcontrib>Zhou, Yingling</creatorcontrib><creatorcontrib>Li, Liwen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Anping</au><au>Li, Xida</au><au>Zhong, Qi</au><au>Li, Minming</au><au>Wang, Rui</au><au>Liang, Yingcong</au><au>Chen, Wenzhong</au><au>Huang, Tehui</au><au>Li, Xiaohong</au><au>Zhou, Yingling</au><au>Li, Liwen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of high HDL cholesterol level with all-cause mortality in patients with heart failure complicating coronary heart disease</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2016-07-01</date><risdate>2016</risdate><volume>95</volume><issue>28</issue><spage>e3974</spage><epage>e3974</epage><pages>e3974-e3974</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The aim of the present study was to evaluate the association between HDL cholesterol level and all-cause mortality in patients with ejection fraction reduced heart failure (EFrHF) complicating coronary heart disease (CHD).A total of 323 patients were retrospectively recruited. Patients were divided into low and high HDL cholesterol groups. Between-group differences and associations between HDL cholesterol level and all-cause mortality were assessed.Patients in the high HDL cholesterol group had higher HDL cholesterol level and other lipid components (P <0.05 for all comparison). Lower levels of alanine aminotransferase (ALT), high-sensitivity C-reactive protein (Hs-CRP), and higher albumin (ALB) level were observed in the high HDL cholesterol group (P <0.05 for all comparison). Although left ventricular ejection fraction (LVEF) were comparable (28.8 ± 4.5% vs 28.4 ± 4.6%, P = 0.358), mean mortality rate in the high HDL cholesterol group was significantly lower (43.5% vs 59.1%, P = 0.007). HDL cholesterol level was positively correlated with ALB level, while inversely correlated with ALT, Hs-CRP, and NYHA classification. Logistic regression analysis revealed that after extensively adjusted for confounding variates, HDL cholesterol level remained significantly associated with all-cause mortality although the magnitude of association was gradually attenuated with odds ratio of 0.007 (95% confidence interval 0.001-0.327, P = 0.012).Higher HDL cholesterol level is associated with better survival in patients with EFrHF complicating CHD, and future studies are necessary to demonstrate whether increasing HDL cholesterol level will confer survival benefit in these populations of patients.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>27428188</pmid><doi>10.1097/MD.0000000000003974</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | China - epidemiology Cholesterol, HDL - blood Coronary Artery Disease - blood Coronary Artery Disease - complications Coronary Artery Disease - mortality Female Heart Failure - blood Heart Failure - etiology Heart Failure - mortality Humans Hypercholesterolemia - blood Male Middle Aged Observational Study Retrospective Studies |
| title | Associations of high HDL cholesterol level with all-cause mortality in patients with heart failure complicating coronary heart disease |
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