The Methylcytosine Dioxygenase Tet2 Promotes DNA Demethylation and Activation of Cytokine Gene Expression in T Cells

Epigenetic regulation of lineage-specific genes is important for the differentiation and function of T cells. Ten-eleven translocation (Tet) proteins catalyze 5-methylcytosine (5mC) conversion to 5-hydroxymethylcytosine (5hmC) to mediate DNA demethylation. However, the roles of Tet proteins in the i...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-04, Vol.42 (4), p.613-626
Hauptverfasser:	Ichiyama, Kenji, Chen, Tingting, Wang, Xiaohu, Yan, Xiaowei, Kim, Byung-Seok, Tanaka, Shinya, Ndiaye-Lobry, Delphine, Deng, Yuhua, Zou, Yanli, Zheng, Pan, Tian, Qiang, Aifantis, Iannis, Wei, Lai, Dong, Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - analogs & derivatives Animals Binding sites Cell Differentiation Cytokines - biosynthesis Cytokines - immunology Cytosine - analogs & derivatives Cytosine - immunology Cytosine - metabolism Deoxyribonucleic acid DNA DNA - immunology DNA - metabolism DNA Methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology E1A-Associated p300 Protein - genetics E1A-Associated p300 Protein - immunology Epigenesis, Genetic - immunology Epigenetics Experiments Gene expression Gene Expression Regulation Genetic testing Genome Genomes Humans Lymphocytes Mice Mice, Transgenic Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - immunology Rodents STAT4 Transcription Factor - genetics STAT4 Transcription Factor - immunology T-Box Domain Proteins - genetics T-Box Domain Proteins - immunology Th1 Cells - cytology Th1 Cells - enzymology Th1 Cells - immunology Th17 Cells - cytology Th17 Cells - enzymology Th17 Cells - immunology Transcription factors
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