Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study
Background Albuminuria and proteinuria are known risk factors for premature death. This study compared the ability of albuminuria and proteinuria to predict mortality in a community-based population. Methods We evaluated the urinary albumin creatinine ratio (ACR) and proteinuria by dipstick at a bas...
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| Veröffentlicht in: | Clinical and experimental nephrology 2016-08, Vol.20 (4), p.611-617 |
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| creator | Sato, Hiroko Konta, Tsuneo Ichikawa, Kazunobu Suzuki, Natsuko Kabasawa, Asami Suzuki, Kazuko Hirayama, Atsushi Shibata, Yoko Watanabe, Tetsu Kato, Takeo Ueno, Yoshiyuki Kayama, Takamasa Kubota, Isao |
| description | Background
Albuminuria and proteinuria are known risk factors for premature death. This study compared the ability of albuminuria and proteinuria to predict mortality in a community-based population.
Methods
We evaluated the urinary albumin creatinine ratio (ACR) and proteinuria by dipstick at a baseline survey and examined the association between the 7-year mortality and three categories (albuminuria [ACR ≥ 30 mg/g], trace proteinuria, and ≥[1+] proteinuria) in 3446 Japanese subjects at a local health check.
Results
Albuminuria, ≥trace proteinuria, and ≥(1+) proteinuria were identified in 514 (14.9 %), 290 (8.4 %), and 151 (4.4 %) subjects, respectively. There were 138 deaths during the follow-up period, including 41 cardiovascular deaths. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in ACR and proteinuria levels (log-rank
P
|
| doi_str_mv | 10.1007/s10157-015-1193-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4956708</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4146224781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c648t-4bf0d96a5e4764ea47d65e6949f21350477ad23d6d130515918a4de736c1d90a3</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEoqXwA7igSFzKIeBJ_BFzqIRWfKoSl3LgZM3Gzq7bxA62U2n_Bz8YZ3epChISl_FI7zOvZ-wpiudAXgMh4k0EAkxUOVQAsqnIg-IUaCMqIaR8mPOG1hUIBifFkxivCSGtZPJxcVJzRmvC2Gnxc-XHCYON3pW-L9PWlFMw2nbJ3poS13awabcoOKzn0bo5WCzR6VLbKSbb3WTcJ3MUeh_K0YeE-yrr9n5fcEJnYjb20zxgst693QvfccQNJizPr_AGtzl7VcY0693T4lGPQzTPjudZ8e3D-6vVp-ry68fPq3eXVcdpmyq67omWHJmhglODVGjODJdU9jU0jFAhUNeN5hoawoBJaJFqIxregZYEm7Pi4uA7zevR6M64FHBQU7Ajhp3yaNWfirNbtfG3ikrGBWmzwfnRIPgfs4lJjTZ2ZhjywH6OClqAVgrGyH-ghFPatBwy-vIv9NrPweWX2Bsuv1rXmYID1QUfYzD9Xd9A1LIe6rAeKge1rIdamnhxf-C7it_7kIH6AMQsuY0J967-p-svFojHdg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1811134222</pqid></control><display><type>article</type><title>Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Sato, Hiroko ; Konta, Tsuneo ; Ichikawa, Kazunobu ; Suzuki, Natsuko ; Kabasawa, Asami ; Suzuki, Kazuko ; Hirayama, Atsushi ; Shibata, Yoko ; Watanabe, Tetsu ; Kato, Takeo ; Ueno, Yoshiyuki ; Kayama, Takamasa ; Kubota, Isao</creator><creatorcontrib>Sato, Hiroko ; Konta, Tsuneo ; Ichikawa, Kazunobu ; Suzuki, Natsuko ; Kabasawa, Asami ; Suzuki, Kazuko ; Hirayama, Atsushi ; Shibata, Yoko ; Watanabe, Tetsu ; Kato, Takeo ; Ueno, Yoshiyuki ; Kayama, Takamasa ; Kubota, Isao</creatorcontrib><description>Background
Albuminuria and proteinuria are known risk factors for premature death. This study compared the ability of albuminuria and proteinuria to predict mortality in a community-based population.
Methods
We evaluated the urinary albumin creatinine ratio (ACR) and proteinuria by dipstick at a baseline survey and examined the association between the 7-year mortality and three categories (albuminuria [ACR ≥ 30 mg/g], trace proteinuria, and ≥[1+] proteinuria) in 3446 Japanese subjects at a local health check.
Results
Albuminuria, ≥trace proteinuria, and ≥(1+) proteinuria were identified in 514 (14.9 %), 290 (8.4 %), and 151 (4.4 %) subjects, respectively. There were 138 deaths during the follow-up period, including 41 cardiovascular deaths. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in ACR and proteinuria levels (log-rank
P
< 0.01). The mortality rate (deaths per 1000 person-year) was higher in subjects with albuminuria (12.8), ≥trace proteinuria (12.6), and ≥(1+) proteinuria (16.2) than in all subjects (6.9). A Cox proportional hazard model analysis showed that all three categories were significant predictors of all-cause mortality in the unadjusted model, although after adjustment for possible confounders, a significant association was observed only with albuminuria. Albuminuria, but not proteinuria, was a significant predictor of cardiovascular mortality in both the unadjusted and adjusted models.
Conclusion
Albuminuria had a high prevalence and was strongly associated with mortality, as compared with proteinuria by dipstick, suggesting that albuminuria might be a superior predictor of poor prognosis in the Japanese population.</description><identifier>ISSN: 1342-1751</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-015-1193-0</identifier><identifier>PMID: 26542055</identifier><identifier>CODEN: CENPFV</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Aged ; Albuminuria - mortality ; Albuminuria - urine ; Female ; Humans ; Japan - epidemiology ; Kaplan-Meier Estimate ; Longitudinal Studies ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Original ; Original Article ; Reagent Strips ; Urology</subject><ispartof>Clinical and experimental nephrology, 2016-08, Vol.20 (4), p.611-617</ispartof><rights>The Author(s) 2015</rights><rights>Japanese Society of Nephrology 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c648t-4bf0d96a5e4764ea47d65e6949f21350477ad23d6d130515918a4de736c1d90a3</citedby><cites>FETCH-LOGICAL-c648t-4bf0d96a5e4764ea47d65e6949f21350477ad23d6d130515918a4de736c1d90a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10157-015-1193-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10157-015-1193-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26542055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Hiroko</creatorcontrib><creatorcontrib>Konta, Tsuneo</creatorcontrib><creatorcontrib>Ichikawa, Kazunobu</creatorcontrib><creatorcontrib>Suzuki, Natsuko</creatorcontrib><creatorcontrib>Kabasawa, Asami</creatorcontrib><creatorcontrib>Suzuki, Kazuko</creatorcontrib><creatorcontrib>Hirayama, Atsushi</creatorcontrib><creatorcontrib>Shibata, Yoko</creatorcontrib><creatorcontrib>Watanabe, Tetsu</creatorcontrib><creatorcontrib>Kato, Takeo</creatorcontrib><creatorcontrib>Ueno, Yoshiyuki</creatorcontrib><creatorcontrib>Kayama, Takamasa</creatorcontrib><creatorcontrib>Kubota, Isao</creatorcontrib><title>Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><addtitle>Clin Exp Nephrol</addtitle><description>Background
Albuminuria and proteinuria are known risk factors for premature death. This study compared the ability of albuminuria and proteinuria to predict mortality in a community-based population.
Methods
We evaluated the urinary albumin creatinine ratio (ACR) and proteinuria by dipstick at a baseline survey and examined the association between the 7-year mortality and three categories (albuminuria [ACR ≥ 30 mg/g], trace proteinuria, and ≥[1+] proteinuria) in 3446 Japanese subjects at a local health check.
Results
Albuminuria, ≥trace proteinuria, and ≥(1+) proteinuria were identified in 514 (14.9 %), 290 (8.4 %), and 151 (4.4 %) subjects, respectively. There were 138 deaths during the follow-up period, including 41 cardiovascular deaths. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in ACR and proteinuria levels (log-rank
P
< 0.01). The mortality rate (deaths per 1000 person-year) was higher in subjects with albuminuria (12.8), ≥trace proteinuria (12.6), and ≥(1+) proteinuria (16.2) than in all subjects (6.9). A Cox proportional hazard model analysis showed that all three categories were significant predictors of all-cause mortality in the unadjusted model, although after adjustment for possible confounders, a significant association was observed only with albuminuria. Albuminuria, but not proteinuria, was a significant predictor of cardiovascular mortality in both the unadjusted and adjusted models.
Conclusion
Albuminuria had a high prevalence and was strongly associated with mortality, as compared with proteinuria by dipstick, suggesting that albuminuria might be a superior predictor of poor prognosis in the Japanese population.</description><subject>Aged</subject><subject>Albuminuria - mortality</subject><subject>Albuminuria - urine</subject><subject>Female</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Kaplan-Meier Estimate</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Original</subject><subject>Original Article</subject><subject>Reagent Strips</subject><subject>Urology</subject><issn>1342-1751</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkk1v1DAQhiMEoqXwA7igSFzKIeBJ_BFzqIRWfKoSl3LgZM3Gzq7bxA62U2n_Bz8YZ3epChISl_FI7zOvZ-wpiudAXgMh4k0EAkxUOVQAsqnIg-IUaCMqIaR8mPOG1hUIBifFkxivCSGtZPJxcVJzRmvC2Gnxc-XHCYON3pW-L9PWlFMw2nbJ3poS13awabcoOKzn0bo5WCzR6VLbKSbb3WTcJ3MUeh_K0YeE-yrr9n5fcEJnYjb20zxgst693QvfccQNJizPr_AGtzl7VcY0693T4lGPQzTPjudZ8e3D-6vVp-ry68fPq3eXVcdpmyq67omWHJmhglODVGjODJdU9jU0jFAhUNeN5hoawoBJaJFqIxregZYEm7Pi4uA7zevR6M64FHBQU7Ajhp3yaNWfirNbtfG3ikrGBWmzwfnRIPgfs4lJjTZ2ZhjywH6OClqAVgrGyH-ghFPatBwy-vIv9NrPweWX2Bsuv1rXmYID1QUfYzD9Xd9A1LIe6rAeKge1rIdamnhxf-C7it_7kIH6AMQsuY0J967-p-svFojHdg</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Sato, Hiroko</creator><creator>Konta, Tsuneo</creator><creator>Ichikawa, Kazunobu</creator><creator>Suzuki, Natsuko</creator><creator>Kabasawa, Asami</creator><creator>Suzuki, Kazuko</creator><creator>Hirayama, Atsushi</creator><creator>Shibata, Yoko</creator><creator>Watanabe, Tetsu</creator><creator>Kato, Takeo</creator><creator>Ueno, Yoshiyuki</creator><creator>Kayama, Takamasa</creator><creator>Kubota, Isao</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160801</creationdate><title>Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study</title><author>Sato, Hiroko ; Konta, Tsuneo ; Ichikawa, Kazunobu ; Suzuki, Natsuko ; Kabasawa, Asami ; Suzuki, Kazuko ; Hirayama, Atsushi ; Shibata, Yoko ; Watanabe, Tetsu ; Kato, Takeo ; Ueno, Yoshiyuki ; Kayama, Takamasa ; Kubota, Isao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c648t-4bf0d96a5e4764ea47d65e6949f21350477ad23d6d130515918a4de736c1d90a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Albuminuria - mortality</topic><topic>Albuminuria - urine</topic><topic>Female</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Kaplan-Meier Estimate</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Original</topic><topic>Original Article</topic><topic>Reagent Strips</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Hiroko</creatorcontrib><creatorcontrib>Konta, Tsuneo</creatorcontrib><creatorcontrib>Ichikawa, Kazunobu</creatorcontrib><creatorcontrib>Suzuki, Natsuko</creatorcontrib><creatorcontrib>Kabasawa, Asami</creatorcontrib><creatorcontrib>Suzuki, Kazuko</creatorcontrib><creatorcontrib>Hirayama, Atsushi</creatorcontrib><creatorcontrib>Shibata, Yoko</creatorcontrib><creatorcontrib>Watanabe, Tetsu</creatorcontrib><creatorcontrib>Kato, Takeo</creatorcontrib><creatorcontrib>Ueno, Yoshiyuki</creatorcontrib><creatorcontrib>Kayama, Takamasa</creatorcontrib><creatorcontrib>Kubota, Isao</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical and experimental nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, Hiroko</au><au>Konta, Tsuneo</au><au>Ichikawa, Kazunobu</au><au>Suzuki, Natsuko</au><au>Kabasawa, Asami</au><au>Suzuki, Kazuko</au><au>Hirayama, Atsushi</au><au>Shibata, Yoko</au><au>Watanabe, Tetsu</au><au>Kato, Takeo</au><au>Ueno, Yoshiyuki</au><au>Kayama, Takamasa</au><au>Kubota, Isao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study</atitle><jtitle>Clinical and experimental nephrology</jtitle><stitle>Clin Exp Nephrol</stitle><addtitle>Clin Exp Nephrol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>20</volume><issue>4</issue><spage>611</spage><epage>617</epage><pages>611-617</pages><issn>1342-1751</issn><eissn>1437-7799</eissn><coden>CENPFV</coden><abstract>Background
Albuminuria and proteinuria are known risk factors for premature death. This study compared the ability of albuminuria and proteinuria to predict mortality in a community-based population.
Methods
We evaluated the urinary albumin creatinine ratio (ACR) and proteinuria by dipstick at a baseline survey and examined the association between the 7-year mortality and three categories (albuminuria [ACR ≥ 30 mg/g], trace proteinuria, and ≥[1+] proteinuria) in 3446 Japanese subjects at a local health check.
Results
Albuminuria, ≥trace proteinuria, and ≥(1+) proteinuria were identified in 514 (14.9 %), 290 (8.4 %), and 151 (4.4 %) subjects, respectively. There were 138 deaths during the follow-up period, including 41 cardiovascular deaths. A Kaplan–Meier analysis showed that all-cause mortality significantly increased along with the increase in ACR and proteinuria levels (log-rank
P
< 0.01). The mortality rate (deaths per 1000 person-year) was higher in subjects with albuminuria (12.8), ≥trace proteinuria (12.6), and ≥(1+) proteinuria (16.2) than in all subjects (6.9). A Cox proportional hazard model analysis showed that all three categories were significant predictors of all-cause mortality in the unadjusted model, although after adjustment for possible confounders, a significant association was observed only with albuminuria. Albuminuria, but not proteinuria, was a significant predictor of cardiovascular mortality in both the unadjusted and adjusted models.
Conclusion
Albuminuria had a high prevalence and was strongly associated with mortality, as compared with proteinuria by dipstick, suggesting that albuminuria might be a superior predictor of poor prognosis in the Japanese population.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>26542055</pmid><doi>10.1007/s10157-015-1193-0</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Albuminuria - mortality Albuminuria - urine Female Humans Japan - epidemiology Kaplan-Meier Estimate Longitudinal Studies Male Medicine Medicine & Public Health Middle Aged Nephrology Original Original Article Reagent Strips Urology |
| title | Comparison of the predictive ability of albuminuria and dipstick proteinuria for mortality in the Japanese population: the Yamagata (Takahata) study |
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