Interferon-gamma potentiates NMDA receptor signaling in spinal dorsal horn neurons via microglia–neuron interaction

Background Glia–neuron interactions play an important role in the development of neuropathic pain. Expression of the pro-inflammatory cytokne →cytokine Interferon-gamma (IFNγ) is upregulated in the dorsal horn after peripheral nerve injury, and intrathecal IFNγ administration induces mechanical allo...

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Veröffentlicht in:	Molecular pain 2016, Vol.12
Hauptverfasser:	Sonekatsu, Mayumi, Taniguchi, Wataru, Yamanaka, Manabu, Nishio, Naoko, Tsutsui, Shunji, Yamada, Hiroshi, Yoshida, Munehito, Nakatsuka, Terumasa
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Animals Brain slice preparation CC chemokine receptors CCR2 protein Cell Communication - drug effects Chemokine CCL2 - metabolism Dorsal horn Enzyme inhibitors Glutamic acid receptors (ionotropic) Inflammation Interferon gamma Receptor Interferon-gamma - pharmacology Ion Channel Gating - drug effects Male Microglia Microglia - cytology Microglia - drug effects Microglia - metabolism Minocycline Models, Biological Monocyte chemoattractant protein 1 N-Methyl-D-aspartic acid receptors N-Methylaspartate - pharmacology Neuronal-glial interactions Neurons Pain Pain perception Perfusion Peripheral nerves Peripheral neuropathy Posterior Horn Cells - cytology Posterior Horn Cells - drug effects Posterior Horn Cells - metabolism Potentiation Rats, Sprague-Dawley Receptors, CCR2 - metabolism Receptors, Interferon - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction - drug effects Spinal cord Substantia gelatinosa α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid γ-Interferon
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