Family history and the natural history of colorectal cancer: systematic review
Purpose: Family history of colorectal cancer (CRC) is a known risk factor for CRC and encompasses both genetic and shared environmental risks. Methods: We conducted a systematic review to estimate the impact of family history on the natural history of CRC and adherence to screening. Results: We foun...
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| Veröffentlicht in: | Genetics in medicine 2015-09, Vol.17 (9), p.702-712 |
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| creator | Henrikson, Nora B. Webber, Elizabeth M. Goddard, Katrina A. Scrol, Aaron Piper, Margaret Williams, Marc S. Zallen, Doris T. Calonge, Ned Ganiats, Theodore G. Janssens, A. Cecile J.W. Zauber, Ann Lansdorp-Vogelaar, Iris van Ballegooijen, Marjolein Whitlock, Evelyn P. |
| description | Purpose:
Family history of colorectal cancer (CRC) is a known risk factor for CRC and encompasses both genetic and shared environmental risks.
Methods:
We conducted a systematic review to estimate the impact of family history on the natural history of CRC and adherence to screening.
Results:
We found high heterogeneity in family-history definitions, the most common definition being one or more first-degree relatives. The prevalence of family history may be lower than the commonly cited 10%, and confirms evidence for increasing levels of risk associated with increasing family-history burden. There is evidence for higher prevalence of adenomas and of multiple adenomas in people with family history of CRC but no evidence for differential adenoma location or adenoma progression by family history. Limited data regarding the natural history of CRC by family history suggest a differential age or stage at cancer diagnosis and mixed evidence with respect to tumor location. Adherence to recommended colonoscopy screening was higher in people with a family history of CRC.
Conclusion:
Stratification based on polygenic and/or multifactorial risk assessment may mature to the point of displacing family history–based approaches, but for the foreseeable future, family history may remain a valuable clinical tool for identifying individuals at increased risk for CRC.
Genet Med
17
9, 702–712. |
| doi_str_mv | 10.1038/gim.2014.188 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4955831</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4265606531</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-e0918f24f4adb0699398ae1e34b739552fc11a84d46a4cf0f9bf2a99ba99fe343</originalsourceid><addsrcrecordid>eNptkMFLwzAYxYMoTqc3z1LwamfSpG3iQZDhVBh60XNI02TLWJuZpJP-92ZsjgkeQsL3fnnf4wFwheAIQUzvZqYZZRCREaL0CJyhHMMU4qI4jm_IaIoLCAfg3PsFhKjEGTwFgyzPWdTQGXibiMYs-2RufLCuT0RbJ2GuklaEzonlfm51Iu3SOiVDnErRSuXuE9_7oBoRjEycWhv1fQFOtFh6dbm7h-Bz8vQxfkmn78-v48dpKkkOQ6ogQ1RnRBNRV7BgDDMqFFKYVCVmeZ5piZCgpCaFIFJDzSqdCcaqeHSk8BA8bH1XXdWoWqo2xLR85UwjXM-tMPyv0po5n9k1J9GdYhQNbnYGzn51yge-sJ1rY2aOKCFlVsaEkbrdUtJZ753S-w0I8k37PLbPN-3HXxv8-jDVHv6tOwLpFvBRamfKHWz9z_AH9rqQ9Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1844727918</pqid></control><display><type>article</type><title>Family history and the natural history of colorectal cancer: systematic review</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ProQuest Central UK/Ireland</source><source>Alma/SFX Local Collection</source><creator>Henrikson, Nora B. ; Webber, Elizabeth M. ; Goddard, Katrina A. ; Scrol, Aaron ; Piper, Margaret ; Williams, Marc S. ; Zallen, Doris T. ; Calonge, Ned ; Ganiats, Theodore G. ; Janssens, A. Cecile J.W. ; Zauber, Ann ; Lansdorp-Vogelaar, Iris ; van Ballegooijen, Marjolein ; Whitlock, Evelyn P.</creator><creatorcontrib>Henrikson, Nora B. ; Webber, Elizabeth M. ; Goddard, Katrina A. ; Scrol, Aaron ; Piper, Margaret ; Williams, Marc S. ; Zallen, Doris T. ; Calonge, Ned ; Ganiats, Theodore G. ; Janssens, A. Cecile J.W. ; Zauber, Ann ; Lansdorp-Vogelaar, Iris ; van Ballegooijen, Marjolein ; Whitlock, Evelyn P.</creatorcontrib><description>Purpose:
Family history of colorectal cancer (CRC) is a known risk factor for CRC and encompasses both genetic and shared environmental risks.
Methods:
We conducted a systematic review to estimate the impact of family history on the natural history of CRC and adherence to screening.
Results:
We found high heterogeneity in family-history definitions, the most common definition being one or more first-degree relatives. The prevalence of family history may be lower than the commonly cited 10%, and confirms evidence for increasing levels of risk associated with increasing family-history burden. There is evidence for higher prevalence of adenomas and of multiple adenomas in people with family history of CRC but no evidence for differential adenoma location or adenoma progression by family history. Limited data regarding the natural history of CRC by family history suggest a differential age or stage at cancer diagnosis and mixed evidence with respect to tumor location. Adherence to recommended colonoscopy screening was higher in people with a family history of CRC.
Conclusion:
Stratification based on polygenic and/or multifactorial risk assessment may mature to the point of displacing family history–based approaches, but for the foreseeable future, family history may remain a valuable clinical tool for identifying individuals at increased risk for CRC.
Genet Med
17
9, 702–712.</description><identifier>ISSN: 1098-3600</identifier><identifier>EISSN: 1530-0366</identifier><identifier>DOI: 10.1038/gim.2014.188</identifier><identifier>PMID: 25590981</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/208/1516 ; 692/499 ; 692/699/1503/1504/1885 ; Biomedicine ; Colorectal cancer ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Early Detection of Cancer ; Family Health ; Genetic Predisposition to Disease ; Human Genetics ; Humans ; Laboratory Medicine ; Prevalence ; Risk Factors ; systematic-review</subject><ispartof>Genetics in medicine, 2015-09, Vol.17 (9), p.702-712</ispartof><rights>American College of Medical Genetics and Genomics 2015</rights><rights>Copyright Nature Publishing Group Sep 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-e0918f24f4adb0699398ae1e34b739552fc11a84d46a4cf0f9bf2a99ba99fe343</citedby><orcidid>0000-0002-5688-5640 ; 0000-0002-3920-3708 ; 0000-0002-2653-6001 ; 0000-0002-6153-4976 ; 0000-0002-6231-9653 ; 0000-0001-6165-8701 ; 0000-0002-3459-7787</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1844727918?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,64384,64388,72240</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25590981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henrikson, Nora B.</creatorcontrib><creatorcontrib>Webber, Elizabeth M.</creatorcontrib><creatorcontrib>Goddard, Katrina A.</creatorcontrib><creatorcontrib>Scrol, Aaron</creatorcontrib><creatorcontrib>Piper, Margaret</creatorcontrib><creatorcontrib>Williams, Marc S.</creatorcontrib><creatorcontrib>Zallen, Doris T.</creatorcontrib><creatorcontrib>Calonge, Ned</creatorcontrib><creatorcontrib>Ganiats, Theodore G.</creatorcontrib><creatorcontrib>Janssens, A. Cecile J.W.</creatorcontrib><creatorcontrib>Zauber, Ann</creatorcontrib><creatorcontrib>Lansdorp-Vogelaar, Iris</creatorcontrib><creatorcontrib>van Ballegooijen, Marjolein</creatorcontrib><creatorcontrib>Whitlock, Evelyn P.</creatorcontrib><title>Family history and the natural history of colorectal cancer: systematic review</title><title>Genetics in medicine</title><addtitle>Genet Med</addtitle><addtitle>Genet Med</addtitle><description>Purpose:
Family history of colorectal cancer (CRC) is a known risk factor for CRC and encompasses both genetic and shared environmental risks.
Methods:
We conducted a systematic review to estimate the impact of family history on the natural history of CRC and adherence to screening.
Results:
We found high heterogeneity in family-history definitions, the most common definition being one or more first-degree relatives. The prevalence of family history may be lower than the commonly cited 10%, and confirms evidence for increasing levels of risk associated with increasing family-history burden. There is evidence for higher prevalence of adenomas and of multiple adenomas in people with family history of CRC but no evidence for differential adenoma location or adenoma progression by family history. Limited data regarding the natural history of CRC by family history suggest a differential age or stage at cancer diagnosis and mixed evidence with respect to tumor location. Adherence to recommended colonoscopy screening was higher in people with a family history of CRC.
Conclusion:
Stratification based on polygenic and/or multifactorial risk assessment may mature to the point of displacing family history–based approaches, but for the foreseeable future, family history may remain a valuable clinical tool for identifying individuals at increased risk for CRC.
Genet Med
17
9, 702–712.</description><subject>631/208/1516</subject><subject>692/499</subject><subject>692/699/1503/1504/1885</subject><subject>Biomedicine</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Early Detection of Cancer</subject><subject>Family Health</subject><subject>Genetic Predisposition to Disease</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Laboratory Medicine</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>systematic-review</subject><issn>1098-3600</issn><issn>1530-0366</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkMFLwzAYxYMoTqc3z1LwamfSpG3iQZDhVBh60XNI02TLWJuZpJP-92ZsjgkeQsL3fnnf4wFwheAIQUzvZqYZZRCREaL0CJyhHMMU4qI4jm_IaIoLCAfg3PsFhKjEGTwFgyzPWdTQGXibiMYs-2RufLCuT0RbJ2GuklaEzonlfm51Iu3SOiVDnErRSuXuE9_7oBoRjEycWhv1fQFOtFh6dbm7h-Bz8vQxfkmn78-v48dpKkkOQ6ogQ1RnRBNRV7BgDDMqFFKYVCVmeZ5piZCgpCaFIFJDzSqdCcaqeHSk8BA8bH1XXdWoWqo2xLR85UwjXM-tMPyv0po5n9k1J9GdYhQNbnYGzn51yge-sJ1rY2aOKCFlVsaEkbrdUtJZ753S-w0I8k37PLbPN-3HXxv8-jDVHv6tOwLpFvBRamfKHWz9z_AH9rqQ9Q</recordid><startdate>20150901</startdate><enddate>20150901</enddate><creator>Henrikson, Nora B.</creator><creator>Webber, Elizabeth M.</creator><creator>Goddard, Katrina A.</creator><creator>Scrol, Aaron</creator><creator>Piper, Margaret</creator><creator>Williams, Marc S.</creator><creator>Zallen, Doris T.</creator><creator>Calonge, Ned</creator><creator>Ganiats, Theodore G.</creator><creator>Janssens, A. Cecile J.W.</creator><creator>Zauber, Ann</creator><creator>Lansdorp-Vogelaar, Iris</creator><creator>van Ballegooijen, Marjolein</creator><creator>Whitlock, Evelyn P.</creator><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5688-5640</orcidid><orcidid>https://orcid.org/0000-0002-3920-3708</orcidid><orcidid>https://orcid.org/0000-0002-2653-6001</orcidid><orcidid>https://orcid.org/0000-0002-6153-4976</orcidid><orcidid>https://orcid.org/0000-0002-6231-9653</orcidid><orcidid>https://orcid.org/0000-0001-6165-8701</orcidid><orcidid>https://orcid.org/0000-0002-3459-7787</orcidid></search><sort><creationdate>20150901</creationdate><title>Family history and the natural history of colorectal cancer: systematic review</title><author>Henrikson, Nora B. ; Webber, Elizabeth M. ; Goddard, Katrina A. ; Scrol, Aaron ; Piper, Margaret ; Williams, Marc S. ; Zallen, Doris T. ; Calonge, Ned ; Ganiats, Theodore G. ; Janssens, A. Cecile J.W. ; Zauber, Ann ; Lansdorp-Vogelaar, Iris ; van Ballegooijen, Marjolein ; Whitlock, Evelyn P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-e0918f24f4adb0699398ae1e34b739552fc11a84d46a4cf0f9bf2a99ba99fe343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>631/208/1516</topic><topic>692/499</topic><topic>692/699/1503/1504/1885</topic><topic>Biomedicine</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Early Detection of Cancer</topic><topic>Family Health</topic><topic>Genetic Predisposition to Disease</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Laboratory Medicine</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>systematic-review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henrikson, Nora B.</creatorcontrib><creatorcontrib>Webber, Elizabeth M.</creatorcontrib><creatorcontrib>Goddard, Katrina A.</creatorcontrib><creatorcontrib>Scrol, Aaron</creatorcontrib><creatorcontrib>Piper, Margaret</creatorcontrib><creatorcontrib>Williams, Marc S.</creatorcontrib><creatorcontrib>Zallen, Doris T.</creatorcontrib><creatorcontrib>Calonge, Ned</creatorcontrib><creatorcontrib>Ganiats, Theodore G.</creatorcontrib><creatorcontrib>Janssens, A. Cecile J.W.</creatorcontrib><creatorcontrib>Zauber, Ann</creatorcontrib><creatorcontrib>Lansdorp-Vogelaar, Iris</creatorcontrib><creatorcontrib>van Ballegooijen, Marjolein</creatorcontrib><creatorcontrib>Whitlock, Evelyn P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genetics in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henrikson, Nora B.</au><au>Webber, Elizabeth M.</au><au>Goddard, Katrina A.</au><au>Scrol, Aaron</au><au>Piper, Margaret</au><au>Williams, Marc S.</au><au>Zallen, Doris T.</au><au>Calonge, Ned</au><au>Ganiats, Theodore G.</au><au>Janssens, A. Cecile J.W.</au><au>Zauber, Ann</au><au>Lansdorp-Vogelaar, Iris</au><au>van Ballegooijen, Marjolein</au><au>Whitlock, Evelyn P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Family history and the natural history of colorectal cancer: systematic review</atitle><jtitle>Genetics in medicine</jtitle><stitle>Genet Med</stitle><addtitle>Genet Med</addtitle><date>2015-09-01</date><risdate>2015</risdate><volume>17</volume><issue>9</issue><spage>702</spage><epage>712</epage><pages>702-712</pages><issn>1098-3600</issn><eissn>1530-0366</eissn><abstract>Purpose:
Family history of colorectal cancer (CRC) is a known risk factor for CRC and encompasses both genetic and shared environmental risks.
Methods:
We conducted a systematic review to estimate the impact of family history on the natural history of CRC and adherence to screening.
Results:
We found high heterogeneity in family-history definitions, the most common definition being one or more first-degree relatives. The prevalence of family history may be lower than the commonly cited 10%, and confirms evidence for increasing levels of risk associated with increasing family-history burden. There is evidence for higher prevalence of adenomas and of multiple adenomas in people with family history of CRC but no evidence for differential adenoma location or adenoma progression by family history. Limited data regarding the natural history of CRC by family history suggest a differential age or stage at cancer diagnosis and mixed evidence with respect to tumor location. Adherence to recommended colonoscopy screening was higher in people with a family history of CRC.
Conclusion:
Stratification based on polygenic and/or multifactorial risk assessment may mature to the point of displacing family history–based approaches, but for the foreseeable future, family history may remain a valuable clinical tool for identifying individuals at increased risk for CRC.
Genet Med
17
9, 702–712.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>25590981</pmid><doi>10.1038/gim.2014.188</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5688-5640</orcidid><orcidid>https://orcid.org/0000-0002-3920-3708</orcidid><orcidid>https://orcid.org/0000-0002-2653-6001</orcidid><orcidid>https://orcid.org/0000-0002-6153-4976</orcidid><orcidid>https://orcid.org/0000-0002-6231-9653</orcidid><orcidid>https://orcid.org/0000-0001-6165-8701</orcidid><orcidid>https://orcid.org/0000-0002-3459-7787</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/208/1516 692/499 692/699/1503/1504/1885 Biomedicine Colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Early Detection of Cancer Family Health Genetic Predisposition to Disease Human Genetics Humans Laboratory Medicine Prevalence Risk Factors systematic-review |
| title | Family history and the natural history of colorectal cancer: systematic review |
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