Synthesis and investigation of novel benzimidazole derivatives as antifungal agents

[Display omitted] The rise and emergence of resistance to antifungal drugs by diverse pathogenic fungal strains have resulted in an increase in demand for new antifungal agents. Various heterocyclic scaffolds with different mechanisms of action against fungi have been investigated in the past. Herei...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2016-08, Vol.24 (16), p.3680-3686
Hauptverfasser:	Chandrika, Nishad Thamban, Shrestha, Sanjib K., Ngo, Huy X., Garneau-Tsodikova, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Aspergillus Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Candida Carbon-13 Magnetic Resonance Spectroscopy Cytotoxicity Hoechst 33258 Microbial Sensitivity Tests Proton Magnetic Resonance Spectroscopy Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism Yeasts - drug effects Yeasts - metabolism
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