Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test
Mechanical sensitivity is commonly affected in chronic pain and other neurological disorders. To discover mechanisms of individual differences in punctate mechanosensation, we performed quantitative trait locus (QTL) mapping of the response to von Frey monofilament stimulation in BXD recombinant inb...
Gespeichert in:
| Veröffentlicht in: | Genes, brain and behavior brain and behavior, 2016-07, Vol.15 (6), p.604-615 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 615 |
|---|---|
| container_issue | 6 |
| container_start_page | 604 |
| container_title | Genes, brain and behavior |
| container_volume | 15 |
| creator | Young, E. E. Bryant, C. D. Lee, S. E. Peng, X. Cook, B. Nair, H. K. Dreher, K. J. Zhang, X. Palmer, A. A. Chung, J. M. Mogil, J. S. Chesler, E. J. Lariviere, W. R. |
| description | Mechanical sensitivity is commonly affected in chronic pain and other neurological disorders. To discover mechanisms of individual differences in punctate mechanosensation, we performed quantitative trait locus (QTL) mapping of the response to von Frey monofilament stimulation in BXD recombinant inbred (BXD) mice. Significant loci were detected on mouse chromosome (Chr) 5 and 15, indicating the location of underlying polymorphisms that cause heritable variation in von Frey response. Convergent evidence from public gene expression data implicates candidate genes within the loci: von Frey thresholds were strongly correlated with baseline expression of Cacna2d1, Ift27 and Csnk1e in multiple brain regions of BXD strains. Systemic gabapentin and PF‐670462, which target the protein products of Cacna2d1 and Csnk1e, respectively, significantly increased von Frey thresholds in a genotype‐dependent manner in progenitors and BXD strains. Real‐time polymerase chain reaction confirmed differential expression of Cacna2d1 and Csnk1e in multiple brain regions in progenitors and showed differential expression of Cacna2d1 and Csnk1e in the dorsal root ganglia of the progenitors and BXD strains grouped by QTL genotype. Thus, linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 and Csnk1e may contribute to individual differences in von Frey filament response. This study implicates Cacna2d1 and Ift27 in basal mechanosensation in line with their previously suspected role in mechanical hypersensitivity. Csnk1e is implicated for von Frey response for the first time. Further investigation is warranted to identify the specific polymorphisms involved and assess the relevance of these findings to clinical conditions of disturbed mechanosensation.
Two QTL, on chr 5 and 15, were identified for mechanosensation using the BXD RI strain panel. Candidate gene testing supports a role for Cacna2d1 (chr 5) and Csnk1e (chr 15) in mechanosensation variability. |
| doi_str_mv | 10.1111/gbb.12302 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4955286</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4107748901</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4762-b2cacce7128166e5e3fc64630a41739e9336920da43e209225dc343fddab56fd3</originalsourceid><addsrcrecordid>eNqNkU9LHTEUxYNU1FoXfoES6MYunubPTGZmU1CpVhC6aAvuQia5My-SSV6TGe18-6bv2UcVCmaTS_LLuffkIHRMySnN66xv21PKOGE76IAKQhe05ndvtnVR76O3Kd0TQite0z20zyrGKS35Afr1bU4jDAn34GG0Gitv8Gqp4qB0cKG3Wrl8ptycbMLWgB9tZyFhnUFr1AjrlwlP3kB0s_U9HkAvlQ8JfFKjDR5bj8cl4IdcXkWY8QhpfId2O-USHD3th-jH1efvl18Wt1-vby7Pbxe6qARbtEwrraGirKZCQAm806IQnKgim2mg4Vw0jBhVcGCkYaw0mhe8M0a1pegMP0SfNrqrqR3A6GwgKidX0Q4qzjIoK5_feLuUfXiQRVOWrBZZ4ORJIIafU55cDjZpcE55CFOStCa1EFww-hqUFRUXdZnRDy_Q-zDF_M9riubWtGoy9XFD6RhSitBt56ZE_ole5ujlOvrMvv_X6Jb8m3UGzjbAo3Uw_19JXl9cbCR_A3fPuio</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1801552179</pqid></control><display><type>article</type><title>Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test</title><source>Wiley Online Library (Open Access Collection)</source><creator>Young, E. E. ; Bryant, C. D. ; Lee, S. E. ; Peng, X. ; Cook, B. ; Nair, H. K. ; Dreher, K. J. ; Zhang, X. ; Palmer, A. A. ; Chung, J. M. ; Mogil, J. S. ; Chesler, E. J. ; Lariviere, W. R.</creator><creatorcontrib>Young, E. E. ; Bryant, C. D. ; Lee, S. E. ; Peng, X. ; Cook, B. ; Nair, H. K. ; Dreher, K. J. ; Zhang, X. ; Palmer, A. A. ; Chung, J. M. ; Mogil, J. S. ; Chesler, E. J. ; Lariviere, W. R.</creatorcontrib><description>Mechanical sensitivity is commonly affected in chronic pain and other neurological disorders. To discover mechanisms of individual differences in punctate mechanosensation, we performed quantitative trait locus (QTL) mapping of the response to von Frey monofilament stimulation in BXD recombinant inbred (BXD) mice. Significant loci were detected on mouse chromosome (Chr) 5 and 15, indicating the location of underlying polymorphisms that cause heritable variation in von Frey response. Convergent evidence from public gene expression data implicates candidate genes within the loci: von Frey thresholds were strongly correlated with baseline expression of Cacna2d1, Ift27 and Csnk1e in multiple brain regions of BXD strains. Systemic gabapentin and PF‐670462, which target the protein products of Cacna2d1 and Csnk1e, respectively, significantly increased von Frey thresholds in a genotype‐dependent manner in progenitors and BXD strains. Real‐time polymerase chain reaction confirmed differential expression of Cacna2d1 and Csnk1e in multiple brain regions in progenitors and showed differential expression of Cacna2d1 and Csnk1e in the dorsal root ganglia of the progenitors and BXD strains grouped by QTL genotype. Thus, linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 and Csnk1e may contribute to individual differences in von Frey filament response. This study implicates Cacna2d1 and Ift27 in basal mechanosensation in line with their previously suspected role in mechanical hypersensitivity. Csnk1e is implicated for von Frey response for the first time. Further investigation is warranted to identify the specific polymorphisms involved and assess the relevance of these findings to clinical conditions of disturbed mechanosensation.
Two QTL, on chr 5 and 15, were identified for mechanosensation using the BXD RI strain panel. Candidate gene testing supports a role for Cacna2d1 (chr 5) and Csnk1e (chr 15) in mechanosensation variability.</description><identifier>ISSN: 1601-1848</identifier><identifier>EISSN: 1601-183X</identifier><identifier>DOI: 10.1111/gbb.12302</identifier><identifier>PMID: 27231153</identifier><identifier>CODEN: GBBEAO</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Amines - pharmacology ; Analgesics - pharmacology ; Animals ; Brain ; Calcium Channels - genetics ; Calcium Channels - metabolism ; Casein kinase 1 ; Casein Kinase I - genetics ; Casein Kinase I - metabolism ; Cyclohexanecarboxylic Acids - pharmacology ; Gabapentin ; gamma-Aminobutyric Acid - pharmacology ; Ganglia, Spinal - drug effects ; Ganglia, Spinal - metabolism ; Ganglia, Spinal - physiology ; Gene expression ; linkage mapping ; Male ; Mechanotransduction, Cellular - genetics ; Mice ; microarray ; Pyrimidines - pharmacology ; Quantitative Trait Loci ; quantitative trait locus ; rab GTP-Binding Proteins - genetics ; rab GTP-Binding Proteins - metabolism ; Sensory Thresholds ; Touch - drug effects ; Touch - genetics ; transcript abundance ; voltage‐gated calcium channels ; von Frey</subject><ispartof>Genes, brain and behavior, 2016-07, Vol.15 (6), p.604-615</ispartof><rights>2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society</rights><rights>2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4762-b2cacce7128166e5e3fc64630a41739e9336920da43e209225dc343fddab56fd3</citedby><cites>FETCH-LOGICAL-c4762-b2cacce7128166e5e3fc64630a41739e9336920da43e209225dc343fddab56fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fgbb.12302$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fgbb.12302$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fgbb.12302$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27231153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Young, E. E.</creatorcontrib><creatorcontrib>Bryant, C. D.</creatorcontrib><creatorcontrib>Lee, S. E.</creatorcontrib><creatorcontrib>Peng, X.</creatorcontrib><creatorcontrib>Cook, B.</creatorcontrib><creatorcontrib>Nair, H. K.</creatorcontrib><creatorcontrib>Dreher, K. J.</creatorcontrib><creatorcontrib>Zhang, X.</creatorcontrib><creatorcontrib>Palmer, A. A.</creatorcontrib><creatorcontrib>Chung, J. M.</creatorcontrib><creatorcontrib>Mogil, J. S.</creatorcontrib><creatorcontrib>Chesler, E. J.</creatorcontrib><creatorcontrib>Lariviere, W. R.</creatorcontrib><title>Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test</title><title>Genes, brain and behavior</title><addtitle>Genes Brain Behav</addtitle><description>Mechanical sensitivity is commonly affected in chronic pain and other neurological disorders. To discover mechanisms of individual differences in punctate mechanosensation, we performed quantitative trait locus (QTL) mapping of the response to von Frey monofilament stimulation in BXD recombinant inbred (BXD) mice. Significant loci were detected on mouse chromosome (Chr) 5 and 15, indicating the location of underlying polymorphisms that cause heritable variation in von Frey response. Convergent evidence from public gene expression data implicates candidate genes within the loci: von Frey thresholds were strongly correlated with baseline expression of Cacna2d1, Ift27 and Csnk1e in multiple brain regions of BXD strains. Systemic gabapentin and PF‐670462, which target the protein products of Cacna2d1 and Csnk1e, respectively, significantly increased von Frey thresholds in a genotype‐dependent manner in progenitors and BXD strains. Real‐time polymerase chain reaction confirmed differential expression of Cacna2d1 and Csnk1e in multiple brain regions in progenitors and showed differential expression of Cacna2d1 and Csnk1e in the dorsal root ganglia of the progenitors and BXD strains grouped by QTL genotype. Thus, linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 and Csnk1e may contribute to individual differences in von Frey filament response. This study implicates Cacna2d1 and Ift27 in basal mechanosensation in line with their previously suspected role in mechanical hypersensitivity. Csnk1e is implicated for von Frey response for the first time. Further investigation is warranted to identify the specific polymorphisms involved and assess the relevance of these findings to clinical conditions of disturbed mechanosensation.
Two QTL, on chr 5 and 15, were identified for mechanosensation using the BXD RI strain panel. Candidate gene testing supports a role for Cacna2d1 (chr 5) and Csnk1e (chr 15) in mechanosensation variability.</description><subject>Amines - pharmacology</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Brain</subject><subject>Calcium Channels - genetics</subject><subject>Calcium Channels - metabolism</subject><subject>Casein kinase 1</subject><subject>Casein Kinase I - genetics</subject><subject>Casein Kinase I - metabolism</subject><subject>Cyclohexanecarboxylic Acids - pharmacology</subject><subject>Gabapentin</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Ganglia, Spinal - drug effects</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Ganglia, Spinal - physiology</subject><subject>Gene expression</subject><subject>linkage mapping</subject><subject>Male</subject><subject>Mechanotransduction, Cellular - genetics</subject><subject>Mice</subject><subject>microarray</subject><subject>Pyrimidines - pharmacology</subject><subject>Quantitative Trait Loci</subject><subject>quantitative trait locus</subject><subject>rab GTP-Binding Proteins - genetics</subject><subject>rab GTP-Binding Proteins - metabolism</subject><subject>Sensory Thresholds</subject><subject>Touch - drug effects</subject><subject>Touch - genetics</subject><subject>transcript abundance</subject><subject>voltage‐gated calcium channels</subject><subject>von Frey</subject><issn>1601-1848</issn><issn>1601-183X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9LHTEUxYNU1FoXfoES6MYunubPTGZmU1CpVhC6aAvuQia5My-SSV6TGe18-6bv2UcVCmaTS_LLuffkIHRMySnN66xv21PKOGE76IAKQhe05ndvtnVR76O3Kd0TQite0z20zyrGKS35Afr1bU4jDAn34GG0Gitv8Gqp4qB0cKG3Wrl8ptycbMLWgB9tZyFhnUFr1AjrlwlP3kB0s_U9HkAvlQ8JfFKjDR5bj8cl4IdcXkWY8QhpfId2O-USHD3th-jH1efvl18Wt1-vby7Pbxe6qARbtEwrraGirKZCQAm806IQnKgim2mg4Vw0jBhVcGCkYaw0mhe8M0a1pegMP0SfNrqrqR3A6GwgKidX0Q4qzjIoK5_feLuUfXiQRVOWrBZZ4ORJIIafU55cDjZpcE55CFOStCa1EFww-hqUFRUXdZnRDy_Q-zDF_M9riubWtGoy9XFD6RhSitBt56ZE_ole5ujlOvrMvv_X6Jb8m3UGzjbAo3Uw_19JXl9cbCR_A3fPuio</recordid><startdate>201607</startdate><enddate>201607</enddate><creator>Young, E. E.</creator><creator>Bryant, C. D.</creator><creator>Lee, S. E.</creator><creator>Peng, X.</creator><creator>Cook, B.</creator><creator>Nair, H. K.</creator><creator>Dreher, K. J.</creator><creator>Zhang, X.</creator><creator>Palmer, A. A.</creator><creator>Chung, J. M.</creator><creator>Mogil, J. S.</creator><creator>Chesler, E. J.</creator><creator>Lariviere, W. R.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201607</creationdate><title>Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test</title><author>Young, E. E. ; Bryant, C. D. ; Lee, S. E. ; Peng, X. ; Cook, B. ; Nair, H. K. ; Dreher, K. J. ; Zhang, X. ; Palmer, A. A. ; Chung, J. M. ; Mogil, J. S. ; Chesler, E. J. ; Lariviere, W. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4762-b2cacce7128166e5e3fc64630a41739e9336920da43e209225dc343fddab56fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Amines - pharmacology</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Brain</topic><topic>Calcium Channels - genetics</topic><topic>Calcium Channels - metabolism</topic><topic>Casein kinase 1</topic><topic>Casein Kinase I - genetics</topic><topic>Casein Kinase I - metabolism</topic><topic>Cyclohexanecarboxylic Acids - pharmacology</topic><topic>Gabapentin</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Ganglia, Spinal - drug effects</topic><topic>Ganglia, Spinal - metabolism</topic><topic>Ganglia, Spinal - physiology</topic><topic>Gene expression</topic><topic>linkage mapping</topic><topic>Male</topic><topic>Mechanotransduction, Cellular - genetics</topic><topic>Mice</topic><topic>microarray</topic><topic>Pyrimidines - pharmacology</topic><topic>Quantitative Trait Loci</topic><topic>quantitative trait locus</topic><topic>rab GTP-Binding Proteins - genetics</topic><topic>rab GTP-Binding Proteins - metabolism</topic><topic>Sensory Thresholds</topic><topic>Touch - drug effects</topic><topic>Touch - genetics</topic><topic>transcript abundance</topic><topic>voltage‐gated calcium channels</topic><topic>von Frey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Young, E. E.</creatorcontrib><creatorcontrib>Bryant, C. D.</creatorcontrib><creatorcontrib>Lee, S. E.</creatorcontrib><creatorcontrib>Peng, X.</creatorcontrib><creatorcontrib>Cook, B.</creatorcontrib><creatorcontrib>Nair, H. K.</creatorcontrib><creatorcontrib>Dreher, K. J.</creatorcontrib><creatorcontrib>Zhang, X.</creatorcontrib><creatorcontrib>Palmer, A. A.</creatorcontrib><creatorcontrib>Chung, J. M.</creatorcontrib><creatorcontrib>Mogil, J. S.</creatorcontrib><creatorcontrib>Chesler, E. J.</creatorcontrib><creatorcontrib>Lariviere, W. R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genes, brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Young, E. E.</au><au>Bryant, C. D.</au><au>Lee, S. E.</au><au>Peng, X.</au><au>Cook, B.</au><au>Nair, H. K.</au><au>Dreher, K. J.</au><au>Zhang, X.</au><au>Palmer, A. A.</au><au>Chung, J. M.</au><au>Mogil, J. S.</au><au>Chesler, E. J.</au><au>Lariviere, W. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test</atitle><jtitle>Genes, brain and behavior</jtitle><addtitle>Genes Brain Behav</addtitle><date>2016-07</date><risdate>2016</risdate><volume>15</volume><issue>6</issue><spage>604</spage><epage>615</epage><pages>604-615</pages><issn>1601-1848</issn><eissn>1601-183X</eissn><coden>GBBEAO</coden><abstract>Mechanical sensitivity is commonly affected in chronic pain and other neurological disorders. To discover mechanisms of individual differences in punctate mechanosensation, we performed quantitative trait locus (QTL) mapping of the response to von Frey monofilament stimulation in BXD recombinant inbred (BXD) mice. Significant loci were detected on mouse chromosome (Chr) 5 and 15, indicating the location of underlying polymorphisms that cause heritable variation in von Frey response. Convergent evidence from public gene expression data implicates candidate genes within the loci: von Frey thresholds were strongly correlated with baseline expression of Cacna2d1, Ift27 and Csnk1e in multiple brain regions of BXD strains. Systemic gabapentin and PF‐670462, which target the protein products of Cacna2d1 and Csnk1e, respectively, significantly increased von Frey thresholds in a genotype‐dependent manner in progenitors and BXD strains. Real‐time polymerase chain reaction confirmed differential expression of Cacna2d1 and Csnk1e in multiple brain regions in progenitors and showed differential expression of Cacna2d1 and Csnk1e in the dorsal root ganglia of the progenitors and BXD strains grouped by QTL genotype. Thus, linkage mapping, transcript covariance and pharmacological testing suggest that genetic variation affecting Cacna2d1 and Csnk1e may contribute to individual differences in von Frey filament response. This study implicates Cacna2d1 and Ift27 in basal mechanosensation in line with their previously suspected role in mechanical hypersensitivity. Csnk1e is implicated for von Frey response for the first time. Further investigation is warranted to identify the specific polymorphisms involved and assess the relevance of these findings to clinical conditions of disturbed mechanosensation.
Two QTL, on chr 5 and 15, were identified for mechanosensation using the BXD RI strain panel. Candidate gene testing supports a role for Cacna2d1 (chr 5) and Csnk1e (chr 15) in mechanosensation variability.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>27231153</pmid><doi>10.1111/gbb.12302</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 1601-1848 |
| ispartof | Genes, brain and behavior, 2016-07, Vol.15 (6), p.604-615 |
| issn | 1601-1848 1601-183X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4955286 |
| source | Wiley Online Library (Open Access Collection) |
| subjects | Amines - pharmacology Analgesics - pharmacology Animals Brain Calcium Channels - genetics Calcium Channels - metabolism Casein kinase 1 Casein Kinase I - genetics Casein Kinase I - metabolism Cyclohexanecarboxylic Acids - pharmacology Gabapentin gamma-Aminobutyric Acid - pharmacology Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism Ganglia, Spinal - physiology Gene expression linkage mapping Male Mechanotransduction, Cellular - genetics Mice microarray Pyrimidines - pharmacology Quantitative Trait Loci quantitative trait locus rab GTP-Binding Proteins - genetics rab GTP-Binding Proteins - metabolism Sensory Thresholds Touch - drug effects Touch - genetics transcript abundance voltage‐gated calcium channels von Frey |
| title | Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T05%3A52%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Systems%20genetic%20and%20pharmacological%20analysis%20identifies%20candidate%20genes%20underlying%20mechanosensation%20in%20the%20von%20Frey%20test&rft.jtitle=Genes,%20brain%20and%20behavior&rft.au=Young,%20E.%20E.&rft.date=2016-07&rft.volume=15&rft.issue=6&rft.spage=604&rft.epage=615&rft.pages=604-615&rft.issn=1601-1848&rft.eissn=1601-183X&rft.coden=GBBEAO&rft_id=info:doi/10.1111/gbb.12302&rft_dat=%3Cproquest_24P%3E4107748901%3C/proquest_24P%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1801552179&rft_id=info:pmid/27231153&rfr_iscdi=true |