Longitudinal associations between bone and adipose tissue biochemical markers with bone mineralization in boys during puberty
We investigated longitudinal relationships between the biochemical markers of bone and adipose tissue with bone mineral content (BMC), bone mineral density (BMD), moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) in pubertal boys. Ninety-six boys (11.9 ± 0.6 years old) were meas...
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| Veröffentlicht in: | BMC pediatrics 2016-07, Vol.16 (1), p.102-102, Article 102 |
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| creator | Vaitkeviciute, Donvina Lätt, Evelin Mäestu, Jarek Jürimäe, Toivo Saar, Meeli Purge, Priit Maasalu, Katre Jürimäe, Jaak |
| description | We investigated longitudinal relationships between the biochemical markers of bone and adipose tissue with bone mineral content (BMC), bone mineral density (BMD), moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) in pubertal boys.
Ninety-six boys (11.9 ± 0.6 years old) were measured at baseline, after 12 and 24 months. Body composition (fat mass [FM], lean body mass [LBM]), and whole body (WB), lumbar spine (LS) and femoral neck (FN) BMD and BMC were assessed. Additionally, serum leptin, adiponectin, osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX) were measured.
OC had a strong longitudinal inverse effect on changes in WB_BMD (p |
| doi_str_mv | 10.1186/s12887-016-0647-1 |
| format | Article |
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Ninety-six boys (11.9 ± 0.6 years old) were measured at baseline, after 12 and 24 months. Body composition (fat mass [FM], lean body mass [LBM]), and whole body (WB), lumbar spine (LS) and femoral neck (FN) BMD and BMC were assessed. Additionally, serum leptin, adiponectin, osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX) were measured.
OC had a strong longitudinal inverse effect on changes in WB_BMD (p < 0.001) and LS_BMD (p = 0.021), while CTX had an inverse effect only on changes in FN_BMD (p = 0.011). Leptin had an inverse effect on changes in WB_BMC/WB_BMD (p = 0.001), FN_BMD (p = 0.002) and LS_BMD (p = 0.001). MVPA showed a longitudinal inverse effect on changes in leptin (p = 0.030), however no longitudinal effect of SED to biochemical markers of bone and adipose tissue was found.
Bone metabolism markers have negative effect on bone mineral accrual during puberty. Increases in MVPA affect leptin, suggesting a positive link of MVPA through leptin metabolism on increases in bone mineralization during puberty.</description><identifier>ISSN: 1471-2431</identifier><identifier>EISSN: 1471-2431</identifier><identifier>DOI: 10.1186/s12887-016-0647-1</identifier><identifier>PMID: 27439435</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adiponectin - blood ; Adiposity - physiology ; Adolescent ; Analysis ; Biological markers ; Biomarkers - blood ; Body composition ; Body fat ; Bone Density - physiology ; Bone Remodeling - physiology ; Bones ; Calcification ; Child ; Children ; Children & youth ; Collagen Type I - blood ; Density ; Exercise ; Exercise - physiology ; Health aspects ; Humans ; Leptin - blood ; Longitudinal Studies ; Male ; Males ; Mineralization ; Models, Statistical ; Osteocalcin - blood ; Peptides - blood ; Puberty ; Puberty - blood ; Puberty - physiology ; Sedentary Lifestyle ; Software ; Statistical analysis ; Teenagers ; Variance analysis</subject><ispartof>BMC pediatrics, 2016-07, Vol.16 (1), p.102-102, Article 102</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-a35721e517a72122b7cd3aa23bf8b69314486edf08de52f43d1be6b01d07cc833</citedby><cites>FETCH-LOGICAL-c486t-a35721e517a72122b7cd3aa23bf8b69314486edf08de52f43d1be6b01d07cc833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955269/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955269/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27439435$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vaitkeviciute, Donvina</creatorcontrib><creatorcontrib>Lätt, Evelin</creatorcontrib><creatorcontrib>Mäestu, Jarek</creatorcontrib><creatorcontrib>Jürimäe, Toivo</creatorcontrib><creatorcontrib>Saar, Meeli</creatorcontrib><creatorcontrib>Purge, Priit</creatorcontrib><creatorcontrib>Maasalu, Katre</creatorcontrib><creatorcontrib>Jürimäe, Jaak</creatorcontrib><title>Longitudinal associations between bone and adipose tissue biochemical markers with bone mineralization in boys during puberty</title><title>BMC pediatrics</title><addtitle>BMC Pediatr</addtitle><description>We investigated longitudinal relationships between the biochemical markers of bone and adipose tissue with bone mineral content (BMC), bone mineral density (BMD), moderate-to-vigorous physical activity (MVPA) and sedentary time (SED) in pubertal boys.
Ninety-six boys (11.9 ± 0.6 years old) were measured at baseline, after 12 and 24 months. Body composition (fat mass [FM], lean body mass [LBM]), and whole body (WB), lumbar spine (LS) and femoral neck (FN) BMD and BMC were assessed. Additionally, serum leptin, adiponectin, osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX) were measured.
OC had a strong longitudinal inverse effect on changes in WB_BMD (p < 0.001) and LS_BMD (p = 0.021), while CTX had an inverse effect only on changes in FN_BMD (p = 0.011). Leptin had an inverse effect on changes in WB_BMC/WB_BMD (p = 0.001), FN_BMD (p = 0.002) and LS_BMD (p = 0.001). MVPA showed a longitudinal inverse effect on changes in leptin (p = 0.030), however no longitudinal effect of SED to biochemical markers of bone and adipose tissue was found.
Bone metabolism markers have negative effect on bone mineral accrual during puberty. Increases in MVPA affect leptin, suggesting a positive link of MVPA through leptin metabolism on increases in bone mineralization during puberty.</description><subject>Adiponectin - blood</subject><subject>Adiposity - physiology</subject><subject>Adolescent</subject><subject>Analysis</subject><subject>Biological markers</subject><subject>Biomarkers - blood</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Bone Density - physiology</subject><subject>Bone Remodeling - physiology</subject><subject>Bones</subject><subject>Calcification</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Collagen Type I - blood</subject><subject>Density</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Males</subject><subject>Mineralization</subject><subject>Models, Statistical</subject><subject>Osteocalcin - blood</subject><subject>Peptides - blood</subject><subject>Puberty</subject><subject>Puberty - blood</subject><subject>Puberty - physiology</subject><subject>Sedentary Lifestyle</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Teenagers</subject><subject>Variance analysis</subject><issn>1471-2431</issn><issn>1471-2431</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkk2LFDEQhoMo7jr6A7xIQBAvrfnqTuYiLItfMOBFzyGdVE9n7U7GTnqXEfzvpmfWYdZcKpCn3qpUvQi9pOQdpap5nyhTSlaENhVphKzoI3RJhaQVE5w-PrtfoGcp3RBCpRLNU3TBpOBrwetL9GcTw9bn2flgBmxSitab7GNIuIV8BxBwGwNgExw2zu9iApx9SjPg1kfbw-htSRzN9BOmhO987o8Jow8wmcH_Pqhhv-jsE3bz5MMW7-YWprx_jp50Zkjw4j6u0I9PH79ff6k23z5_vb7aVFaoJleG15JRqKk0JTLWSuu4MYy3nWqbNaeiYOA6ohzUrBPc0RaallBHpLWK8xX6cNQtdUdwFkIuvend5Evjex2N1w9fgu_1Nt5qsa5rViqs0Nt7gSn-miFlPfpkYRhMgDgnTVVZAJeCiIK-_g-9ifNUpnugFF3zBT1RWzOA9qGLpa5dRPWVaFQ5TC5l35xRPZgh9ykO82FBD0F6BO0UU5qgO_2NEr14RR-9ootX9OIVTUvOq_OhnDL-mYP_Baliu8Q</recordid><startdate>20160720</startdate><enddate>20160720</enddate><creator>Vaitkeviciute, Donvina</creator><creator>Lätt, Evelin</creator><creator>Mäestu, Jarek</creator><creator>Jürimäe, Toivo</creator><creator>Saar, Meeli</creator><creator>Purge, Priit</creator><creator>Maasalu, Katre</creator><creator>Jürimäe, Jaak</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160720</creationdate><title>Longitudinal associations between bone and adipose tissue biochemical markers with bone mineralization in boys during puberty</title><author>Vaitkeviciute, Donvina ; 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Ninety-six boys (11.9 ± 0.6 years old) were measured at baseline, after 12 and 24 months. Body composition (fat mass [FM], lean body mass [LBM]), and whole body (WB), lumbar spine (LS) and femoral neck (FN) BMD and BMC were assessed. Additionally, serum leptin, adiponectin, osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX) were measured.
OC had a strong longitudinal inverse effect on changes in WB_BMD (p < 0.001) and LS_BMD (p = 0.021), while CTX had an inverse effect only on changes in FN_BMD (p = 0.011). Leptin had an inverse effect on changes in WB_BMC/WB_BMD (p = 0.001), FN_BMD (p = 0.002) and LS_BMD (p = 0.001). MVPA showed a longitudinal inverse effect on changes in leptin (p = 0.030), however no longitudinal effect of SED to biochemical markers of bone and adipose tissue was found.
Bone metabolism markers have negative effect on bone mineral accrual during puberty. Increases in MVPA affect leptin, suggesting a positive link of MVPA through leptin metabolism on increases in bone mineralization during puberty.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27439435</pmid><doi>10.1186/s12887-016-0647-1</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adiponectin - blood Adiposity - physiology Adolescent Analysis Biological markers Biomarkers - blood Body composition Body fat Bone Density - physiology Bone Remodeling - physiology Bones Calcification Child Children Children & youth Collagen Type I - blood Density Exercise Exercise - physiology Health aspects Humans Leptin - blood Longitudinal Studies Male Males Mineralization Models, Statistical Osteocalcin - blood Peptides - blood Puberty Puberty - blood Puberty - physiology Sedentary Lifestyle Software Statistical analysis Teenagers Variance analysis |
| title | Longitudinal associations between bone and adipose tissue biochemical markers with bone mineralization in boys during puberty |
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