Human islets and dendritic cells generate post‐translationally modified islet autoantigens

Summary The initiation of type 1 diabetes (T1D) requires a break in peripheral tolerance. New insights into neoepitope formation indicate that post‐translational modification of islet autoantigens, for example via deamidation, may be an important component of disease initiation or exacerbation. Inde...

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Veröffentlicht in:	Clinical and experimental immunology 2016-08, Vol.185 (2), p.133-140
Hauptverfasser:	McLaughlin, R. J., de Haan, A., Zaldumbide, A., de Koning, E. J., de Ru, A. H., van Veelen, P. A., van Lummel, M., Roep, B. O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Autoantigens - biosynthesis Autoantigens - genetics Autoantigens - immunology Autoantigens - metabolism C-Peptide - immunology Dendritic cells Dendritic Cells - immunology Dendritic Cells - physiology Diabetes Mellitus, Type 1 - immunology Enzymes HLA HLA-DQ Antigens - immunology HLA-DR3 Antigen - immunology Humans Immune Tolerance Inflammation - immunology islets Islets of Langerhans - cytology Islets of Langerhans - immunology Islets of Langerhans - physiology Original post‐translational modification Protein Processing, Post-Translational Proteome T cell receptors T-Lymphocytes - immunology Transglutaminases - metabolism type 1 diabetes
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