Pharmacokinetics of mycophenolate sodium co-administered with tacrolimus in the first year after renal transplantation

We assessed the relations between MPA, free MPA (fMPA) and MPA glucuronide (MPAG) pharmacokinetics and the clinical condition of renal transplant recipients treated with EC-MPS and tacrolimus (Tac) in the first post-transplant year. In 18 adult patients blood samples were collected up to 12 h after...

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Veröffentlicht in:	European journal of drug metabolism and pharmacokinetics 2016-08, Vol.41 (4), p.331-338
Hauptverfasser:	Sobiak, Joanna, Resztak, Matylda, Głyda, Maciej, Szczepaniak, Paulina, Chrzanowska, Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Area Under Curve Biomedical and Life Sciences Biomedicine Creatinine - metabolism Drug Therapy, Combination - methods Female Glucuronides - metabolism Human Physiology Humans Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Kidney - drug effects Kidney - metabolism Kidney Transplantation - methods Male Medical Biochemistry Middle Aged Mycophenolic Acid - administration & dosage Mycophenolic Acid - pharmacokinetics Original Paper Pharmaceutical Sciences/Technology Pharmacology/Toxicology Pharmacy Renal Insufficiency - metabolism Tacrolimus - administration & dosage Tacrolimus - pharmacokinetics
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