Integration of human papillomavirus types 16 and 18 in cervical adenocarcinoma
AIMS: To determine which type of human papillomavirus (HPV) is associated with cervical adenocarcinoma and whether the virus was integrated or episomal in two continents. METHODS: Biopsy specimens from the UK (n = 16) and South Africa (n = 22) were analysed by non-isotopic in situ hybridisation (NIS...
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| Veröffentlicht in: | Journal of clinical pathology 1992-05, Vol.45 (5), p.382-384 |
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| creator | Cooper, K Herrington, C S Lo, E S Evans, M F McGee, J O |
| description | AIMS: To determine which type of human papillomavirus (HPV) is associated with cervical adenocarcinoma and whether the virus was integrated or episomal in two continents. METHODS: Biopsy specimens from the UK (n = 16) and South Africa (n = 22) were analysed by non-isotopic in situ hybridisation (NISH) for HPV types 6, 11, 16, 18, 31, 33, and 35 on archival biopsy specimens using digoxigenin labelled probes. RESULTS: A total of 20 adenocarcinomas (53%) from both groups contained HPV DNA. In the UK group, seven and four cases contained HPV 18 (44%) and 16 (25%) respectively. In the South African group, nine cases contained HPV 18 (41%) while HPV DNA was not detectable in the other 13 cases. Hence HPV 18 was present in 80% of HPV positive adenocarcinomas. CONCLUSIONS: The HPV 16 or 18 genome was integrated in all viral positive cases. In two cases HPV 18 was also present in an episomal form. These data indicate that HPV integration is common to cervical adenocarcinoma in two continents by the same methodology. The lower prevalence of HPV 18 detection in the South African group may have been due to the presence of other or unsequenced HPV types. |
| doi_str_mv | 10.1136/jcp.45.5.382 |
| format | Article |
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METHODS: Biopsy specimens from the UK (n = 16) and South Africa (n = 22) were analysed by non-isotopic in situ hybridisation (NISH) for HPV types 6, 11, 16, 18, 31, 33, and 35 on archival biopsy specimens using digoxigenin labelled probes. RESULTS: A total of 20 adenocarcinomas (53%) from both groups contained HPV DNA. In the UK group, seven and four cases contained HPV 18 (44%) and 16 (25%) respectively. In the South African group, nine cases contained HPV 18 (41%) while HPV DNA was not detectable in the other 13 cases. Hence HPV 18 was present in 80% of HPV positive adenocarcinomas. CONCLUSIONS: The HPV 16 or 18 genome was integrated in all viral positive cases. In two cases HPV 18 was also present in an episomal form. These data indicate that HPV integration is common to cervical adenocarcinoma in two continents by the same methodology. The lower prevalence of HPV 18 detection in the South African group may have been due to the presence of other or unsequenced HPV types.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jcp.45.5.382</identifier><identifier>PMID: 1317883</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and Association of Clinical Pathologists</publisher><subject>Adenocarcinoma - microbiology ; Adenocarcinoma - pathology ; Biological and medical sciences ; DNA Probes, HPV ; DNA, Viral - analysis ; Female ; Female genital diseases ; Genome, Viral ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Nucleic Acid Hybridization ; Papillomaviridae - classification ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Uterine Cervical Neoplasms - microbiology ; Uterine Cervical Neoplasms - pathology</subject><ispartof>Journal of clinical pathology, 1992-05, Vol.45 (5), p.382-384</ispartof><rights>1993 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD May 1992</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b4512-e2436a38eba88c011cd04d0df89ac778709bb94b636f09999802eaaee31436853</citedby><cites>FETCH-LOGICAL-b4512-e2436a38eba88c011cd04d0df89ac778709bb94b636f09999802eaaee31436853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC495296/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC495296/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4381522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1317883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooper, K</creatorcontrib><creatorcontrib>Herrington, C S</creatorcontrib><creatorcontrib>Lo, E S</creatorcontrib><creatorcontrib>Evans, M F</creatorcontrib><creatorcontrib>McGee, J O</creatorcontrib><title>Integration of human papillomavirus types 16 and 18 in cervical adenocarcinoma</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>AIMS: To determine which type of human papillomavirus (HPV) is associated with cervical adenocarcinoma and whether the virus was integrated or episomal in two continents. METHODS: Biopsy specimens from the UK (n = 16) and South Africa (n = 22) were analysed by non-isotopic in situ hybridisation (NISH) for HPV types 6, 11, 16, 18, 31, 33, and 35 on archival biopsy specimens using digoxigenin labelled probes. RESULTS: A total of 20 adenocarcinomas (53%) from both groups contained HPV DNA. In the UK group, seven and four cases contained HPV 18 (44%) and 16 (25%) respectively. In the South African group, nine cases contained HPV 18 (41%) while HPV DNA was not detectable in the other 13 cases. Hence HPV 18 was present in 80% of HPV positive adenocarcinomas. CONCLUSIONS: The HPV 16 or 18 genome was integrated in all viral positive cases. In two cases HPV 18 was also present in an episomal form. These data indicate that HPV integration is common to cervical adenocarcinoma in two continents by the same methodology. The lower prevalence of HPV 18 detection in the South African group may have been due to the presence of other or unsequenced HPV types.</description><subject>Adenocarcinoma - microbiology</subject><subject>Adenocarcinoma - pathology</subject><subject>Biological and medical sciences</subject><subject>DNA Probes, HPV</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Genome, Viral</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Nucleic Acid Hybridization</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Uterine Cervical Neoplasms - microbiology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkb2P1DAQxSMEOpaDjhYpEggasnhsJ7YLCrTHx0mnpQFaa-I4d14SJ2cnK-6_x9Gulo8C3Lh4v_c0My_LngJZA7Dqzc6Ma16uyzWT9F62Ai5owYFX97MVIRQKJXj1MHsU444QYALYWXYGDISUbJVtL_1krwNObvD50OY3c48-H3F0XTf0uHdhjvl0N9qYQ5Wjb3KQufO5sWHvDHY5NtYPBoNxPvGPswctdtE-Of7n2dcP779sPhVXnz9ebt5dFTUvgRaWclYhk7ZGKQ0BMA3hDWlaqdAIIQVRda14XbGqJSo9SahFtJZBMsqSnWdvD7njXPe2MdZPATs9BtdjuNMDOv2n4t2Nvh72mquSqir5Xx79YbidbZx076KxXYfeDnPUgioBUoj_glApKihfEp__Be6GOfh0BA1CEF4SUS1xrw-UCUOMwbankYHopU2d2tS81KVObSb82e9r_oIP9SX9xVHHmMpoA3rj4gnjTEJJl5jigLk42R8nGcN3nWYSpd5-2-gLQi-2W6X0ct1XB77ud_8e8Cco_sJG</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>Cooper, K</creator><creator>Herrington, C S</creator><creator>Lo, E S</creator><creator>Evans, M F</creator><creator>McGee, J O</creator><general>BMJ Publishing Group Ltd and Association of Clinical Pathologists</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19920501</creationdate><title>Integration of human papillomavirus types 16 and 18 in cervical adenocarcinoma</title><author>Cooper, K ; Herrington, C S ; Lo, E S ; Evans, M F ; McGee, J O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b4512-e2436a38eba88c011cd04d0df89ac778709bb94b636f09999802eaaee31436853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adenocarcinoma - microbiology</topic><topic>Adenocarcinoma - pathology</topic><topic>Biological and medical sciences</topic><topic>DNA Probes, HPV</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Genome, Viral</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Nucleic Acid Hybridization</topic><topic>Papillomaviridae - classification</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Uterine Cervical Neoplasms - microbiology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cooper, K</creatorcontrib><creatorcontrib>Herrington, C S</creatorcontrib><creatorcontrib>Lo, E S</creatorcontrib><creatorcontrib>Evans, M F</creatorcontrib><creatorcontrib>McGee, J O</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cooper, K</au><au>Herrington, C S</au><au>Lo, E S</au><au>Evans, M F</au><au>McGee, J O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Integration of human papillomavirus types 16 and 18 in cervical adenocarcinoma</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>45</volume><issue>5</issue><spage>382</spage><epage>384</epage><pages>382-384</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>AIMS: To determine which type of human papillomavirus (HPV) is associated with cervical adenocarcinoma and whether the virus was integrated or episomal in two continents. METHODS: Biopsy specimens from the UK (n = 16) and South Africa (n = 22) were analysed by non-isotopic in situ hybridisation (NISH) for HPV types 6, 11, 16, 18, 31, 33, and 35 on archival biopsy specimens using digoxigenin labelled probes. RESULTS: A total of 20 adenocarcinomas (53%) from both groups contained HPV DNA. In the UK group, seven and four cases contained HPV 18 (44%) and 16 (25%) respectively. In the South African group, nine cases contained HPV 18 (41%) while HPV DNA was not detectable in the other 13 cases. Hence HPV 18 was present in 80% of HPV positive adenocarcinomas. CONCLUSIONS: The HPV 16 or 18 genome was integrated in all viral positive cases. In two cases HPV 18 was also present in an episomal form. These data indicate that HPV integration is common to cervical adenocarcinoma in two continents by the same methodology. The lower prevalence of HPV 18 detection in the South African group may have been due to the presence of other or unsequenced HPV types.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and Association of Clinical Pathologists</pub><pmid>1317883</pmid><doi>10.1136/jcp.45.5.382</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical pathology, 1992-05, Vol.45 (5), p.382-384 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - microbiology Adenocarcinoma - pathology Biological and medical sciences DNA Probes, HPV DNA, Viral - analysis Female Female genital diseases Genome, Viral Gynecology. Andrology. Obstetrics Humans Medical sciences Nucleic Acid Hybridization Papillomaviridae - classification Papillomaviridae - genetics Papillomaviridae - isolation & purification Uterine Cervical Neoplasms - microbiology Uterine Cervical Neoplasms - pathology |
| title | Integration of human papillomavirus types 16 and 18 in cervical adenocarcinoma |
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