Solution Structure of a DNA-Binding Unit of Myb: A Helix-Turn-Helix-Related Motif With Conserved Tryptophans Forming a Hydrophobic Core

The DNA-binding domain of the c-myb protooncogene product consists of three imperfect tandem repeats of 51 or 52 amino acids, each of which contains three conserved tryptophans, spaced 18 or 19 amino acids apart. The structure of the third repeat, which is essential for sequence-specific DNA binding...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-07, Vol.89 (14), p.6428-6432
Hauptverfasser:	Ogata, Kazuhiro, Hojo, Hironobu, Aimoto, Saburo, Nakai, Takahisa, Nakamura, Haruki, Sarai, Akinori, Ishii, Shunsuke, Nishimura, Yoshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Animals Biochemistry Biological and medical sciences Computer Graphics Connectivity Deoxyribonucleic acid DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - ultrastructure Fundamental and applied biological sciences. Psychology In Vitro Techniques Magnetic Resonance Spectroscopy Medical research Mice Models, Molecular Molecular biophysics Molecular Sequence Data NMR Nuclear magnetic resonance Nuclear research Protein Conformation Proteins Proto-Oncogene Proteins - ultrastructure Proto-Oncogene Proteins c-myb Protons Research universities Structure in molecular biology Tridimensional structure Tryptophan - chemistry Urban universities
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