Nephrogenic adenoma in elderly patients: Three case reports
Nephrogenic adenoma (NA), referred to as nephrogenic metaplasia, is a rare benign lesion of the urinary tract. NA is histologically characterized by tubular and papillary formations lined by low cuboidal to columnar epithelial cells. NA is also immunohistochemically characterized by positivity for p...
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| Veröffentlicht in: | Molecular and clinical oncology 2016-08, Vol.5 (2), p.253-256 |
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| creator | Sakatani, Toru Adachi, Yasushi Sakaida, Noriko Atsuta, Takeshi Magaribuchi, Toshihiro Taki, Yoji Nakano, Yorika Li, Ming Ikehara, Susumu |
| description | Nephrogenic adenoma (NA), referred to as nephrogenic metaplasia, is a rare benign lesion of the urinary tract. NA is histologically characterized by tubular and papillary formations lined by low cuboidal to columnar epithelial cells. NA is also immunohistochemically characterized by positivity for paired box (PAX) 2, PAX8 and cytokeratin 7, and negative for p63 and prostate-specific antigen. In this study, we present 3 cases of NA arising in the urinary bladder of elderly male patients with predisposing factors: patient 1 had undergone transurethral lithotripsy due to a ureteral stone; patient 2 had undergone transurethral resection of a urothelial carcinoma in the urinary bladder; and patient 3 had been treated with Bacillus-Calmettle-Guérin due to a urothelial carcinoma in the urinary bladder. The characteristics of the NAs of our 3 cases were histologically and immunohistologically consistent with previously reported cases, although 1 patient exhibited a pseudoinvasive pattern. Since NA is a tumor-like benign lesion, it should be clearly differentiated morphologically and immunohistologically from other tumors arising in the urinary tract and from invasion by prostate cancer. |
| doi_str_mv | 10.3892/mco.2016.930 |
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NA is histologically characterized by tubular and papillary formations lined by low cuboidal to columnar epithelial cells. NA is also immunohistochemically characterized by positivity for paired box (PAX) 2, PAX8 and cytokeratin 7, and negative for p63 and prostate-specific antigen. In this study, we present 3 cases of NA arising in the urinary bladder of elderly male patients with predisposing factors: patient 1 had undergone transurethral lithotripsy due to a ureteral stone; patient 2 had undergone transurethral resection of a urothelial carcinoma in the urinary bladder; and patient 3 had been treated with Bacillus-Calmettle-Guérin due to a urothelial carcinoma in the urinary bladder. The characteristics of the NAs of our 3 cases were histologically and immunohistologically consistent with previously reported cases, although 1 patient exhibited a pseudoinvasive pattern. Since NA is a tumor-like benign lesion, it should be clearly differentiated morphologically and immunohistologically from other tumors arising in the urinary tract and from invasion by prostate cancer.</description><identifier>ISSN: 2049-9450</identifier><identifier>EISSN: 2049-9469</identifier><identifier>DOI: 10.3892/mco.2016.930</identifier><identifier>PMID: 27446559</identifier><language>eng</language><publisher>England: D.A. Spandidos</publisher><subject>Adenoma ; Age ; Aged patients ; Antigens ; Bladder ; Bladder cancer ; Care and treatment ; Case reports ; Diagnosis ; elderly patients ; immunohistochemistry ; nephrogenic adenoma ; Oncology ; Patients ; Pediatrics ; Physiological aspects ; predisposing factors ; Prostate cancer ; Tumors ; urinary bladder ; Urogenital system ; Urologic diseases</subject><ispartof>Molecular and clinical oncology, 2016-08, Vol.5 (2), p.253-256</ispartof><rights>Copyright © 2016, Spandidos Publications</rights><rights>COPYRIGHT 2016 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2016</rights><rights>Copyright © 2016, Spandidos Publications 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-e8229df0ec51fc3fe2e71fd93ed1d46fb410c110b36796e731624052716642ec3</citedby><cites>FETCH-LOGICAL-c438t-e8229df0ec51fc3fe2e71fd93ed1d46fb410c110b36796e731624052716642ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950247/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950247/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,5571,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27446559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakatani, Toru</creatorcontrib><creatorcontrib>Adachi, Yasushi</creatorcontrib><creatorcontrib>Sakaida, Noriko</creatorcontrib><creatorcontrib>Atsuta, Takeshi</creatorcontrib><creatorcontrib>Magaribuchi, Toshihiro</creatorcontrib><creatorcontrib>Taki, Yoji</creatorcontrib><creatorcontrib>Nakano, Yorika</creatorcontrib><creatorcontrib>Li, Ming</creatorcontrib><creatorcontrib>Ikehara, Susumu</creatorcontrib><title>Nephrogenic adenoma in elderly patients: Three case reports</title><title>Molecular and clinical oncology</title><addtitle>Mol Clin Oncol</addtitle><description>Nephrogenic adenoma (NA), referred to as nephrogenic metaplasia, is a rare benign lesion of the urinary tract. NA is histologically characterized by tubular and papillary formations lined by low cuboidal to columnar epithelial cells. NA is also immunohistochemically characterized by positivity for paired box (PAX) 2, PAX8 and cytokeratin 7, and negative for p63 and prostate-specific antigen. In this study, we present 3 cases of NA arising in the urinary bladder of elderly male patients with predisposing factors: patient 1 had undergone transurethral lithotripsy due to a ureteral stone; patient 2 had undergone transurethral resection of a urothelial carcinoma in the urinary bladder; and patient 3 had been treated with Bacillus-Calmettle-Guérin due to a urothelial carcinoma in the urinary bladder. The characteristics of the NAs of our 3 cases were histologically and immunohistologically consistent with previously reported cases, although 1 patient exhibited a pseudoinvasive pattern. Since NA is a tumor-like benign lesion, it should be clearly differentiated morphologically and immunohistologically from other tumors arising in the urinary tract and from invasion by prostate cancer.</description><subject>Adenoma</subject><subject>Age</subject><subject>Aged patients</subject><subject>Antigens</subject><subject>Bladder</subject><subject>Bladder cancer</subject><subject>Care and treatment</subject><subject>Case reports</subject><subject>Diagnosis</subject><subject>elderly patients</subject><subject>immunohistochemistry</subject><subject>nephrogenic adenoma</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Physiological aspects</subject><subject>predisposing factors</subject><subject>Prostate cancer</subject><subject>Tumors</subject><subject>urinary bladder</subject><subject>Urogenital system</subject><subject>Urologic diseases</subject><issn>2049-9450</issn><issn>2049-9469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkU1vEzEQhi0EolXpjTNaCQ4c2OBvx1RCqiK-pEIv5Ww59jhxtWsv9gap_x5HKYEiPAeP7Gdez_hF6DnBC7bU9O3o8oJiIhea4UfolGKue82lfnzMBT5B57Xe4ra0wlTop-iEKs6lEPoUXXyDaVvyBlJ0nfWQ8mi7mDoYPJThrpvsHCHN9V13sy0AnbMVugJTLnN9hp4EO1Q4v9_P0PePH25Wn_ur609fVpdXveNsOfewpFT7gMEJEhwLQEGR4DUDTzyXYc0JdoTgNZNKS1CMSMqxoIpIySk4dobeH3Sn3XoE71o_xQ5mKnG05c5kG83DmxS3ZpN_Gq4Fplw1gdf3AiX_2EGdzRirg2GwCfKuGrIUWhHWemjoy3_Q27wrqY1niGaUC8KZ-kNt7AAmppDbu24vai650JxSwnmjFv-hWngYo8sJQmznDwreHApcybUWCMcZCTZ7v03z2-z9Ns3vhr_4-1-O8G93G_DqANTJJh99rkfm6-q6xy32Or8Atlqvbg</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Sakatani, Toru</creator><creator>Adachi, Yasushi</creator><creator>Sakaida, Noriko</creator><creator>Atsuta, Takeshi</creator><creator>Magaribuchi, Toshihiro</creator><creator>Taki, Yoji</creator><creator>Nakano, Yorika</creator><creator>Li, Ming</creator><creator>Ikehara, Susumu</creator><general>D.A. Spandidos</general><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160801</creationdate><title>Nephrogenic adenoma in elderly patients: Three case reports</title><author>Sakatani, Toru ; Adachi, Yasushi ; Sakaida, Noriko ; Atsuta, Takeshi ; Magaribuchi, Toshihiro ; Taki, Yoji ; Nakano, Yorika ; Li, Ming ; Ikehara, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-e8229df0ec51fc3fe2e71fd93ed1d46fb410c110b36796e731624052716642ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adenoma</topic><topic>Age</topic><topic>Aged patients</topic><topic>Antigens</topic><topic>Bladder</topic><topic>Bladder cancer</topic><topic>Care and treatment</topic><topic>Case reports</topic><topic>Diagnosis</topic><topic>elderly patients</topic><topic>immunohistochemistry</topic><topic>nephrogenic adenoma</topic><topic>Oncology</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Physiological aspects</topic><topic>predisposing factors</topic><topic>Prostate cancer</topic><topic>Tumors</topic><topic>urinary bladder</topic><topic>Urogenital system</topic><topic>Urologic diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakatani, Toru</creatorcontrib><creatorcontrib>Adachi, Yasushi</creatorcontrib><creatorcontrib>Sakaida, Noriko</creatorcontrib><creatorcontrib>Atsuta, Takeshi</creatorcontrib><creatorcontrib>Magaribuchi, Toshihiro</creatorcontrib><creatorcontrib>Taki, Yoji</creatorcontrib><creatorcontrib>Nakano, Yorika</creatorcontrib><creatorcontrib>Li, Ming</creatorcontrib><creatorcontrib>Ikehara, Susumu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakatani, Toru</au><au>Adachi, Yasushi</au><au>Sakaida, Noriko</au><au>Atsuta, Takeshi</au><au>Magaribuchi, Toshihiro</au><au>Taki, Yoji</au><au>Nakano, Yorika</au><au>Li, Ming</au><au>Ikehara, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nephrogenic adenoma in elderly patients: Three case reports</atitle><jtitle>Molecular and clinical oncology</jtitle><addtitle>Mol Clin Oncol</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>5</volume><issue>2</issue><spage>253</spage><epage>256</epage><pages>253-256</pages><issn>2049-9450</issn><eissn>2049-9469</eissn><abstract>Nephrogenic adenoma (NA), referred to as nephrogenic metaplasia, is a rare benign lesion of the urinary tract. NA is histologically characterized by tubular and papillary formations lined by low cuboidal to columnar epithelial cells. NA is also immunohistochemically characterized by positivity for paired box (PAX) 2, PAX8 and cytokeratin 7, and negative for p63 and prostate-specific antigen. In this study, we present 3 cases of NA arising in the urinary bladder of elderly male patients with predisposing factors: patient 1 had undergone transurethral lithotripsy due to a ureteral stone; patient 2 had undergone transurethral resection of a urothelial carcinoma in the urinary bladder; and patient 3 had been treated with Bacillus-Calmettle-Guérin due to a urothelial carcinoma in the urinary bladder. The characteristics of the NAs of our 3 cases were histologically and immunohistologically consistent with previously reported cases, although 1 patient exhibited a pseudoinvasive pattern. Since NA is a tumor-like benign lesion, it should be clearly differentiated morphologically and immunohistologically from other tumors arising in the urinary tract and from invasion by prostate cancer.</abstract><cop>England</cop><pub>D.A. Spandidos</pub><pmid>27446559</pmid><doi>10.3892/mco.2016.930</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoma Age Aged patients Antigens Bladder Bladder cancer Care and treatment Case reports Diagnosis elderly patients immunohistochemistry nephrogenic adenoma Oncology Patients Pediatrics Physiological aspects predisposing factors Prostate cancer Tumors urinary bladder Urogenital system Urologic diseases |
| title | Nephrogenic adenoma in elderly patients: Three case reports |
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