Glutamate signals through mGluR2 to control Schwann cell differentiation and proliferation

Rapid saltatory nerve conduction is facilitated by myelin structure, which is produced by Schwann cells (SC) in the peripheral nervous system (PNS). Proper development and degeneration/regeneration after injury requires regulated phenotypic changes of SC. We have previously shown that glutamate can...

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Veröffentlicht in:	Scientific reports 2016-07, Vol.6 (1), p.29856-29856, Article 29856
Hauptverfasser:	Saitoh, Fuminori, Wakatsuki, Shuji, Tokunaga, Shinji, Fujieda, Hiroki, Araki, Toshiyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 13/89 14/63 42/109 631/378/1959 631/378/2606 631/378/340 631/378/87 64/60 82/1 82/80 Animals Cell differentiation Cell Differentiation - genetics Cell Proliferation - genetics Genotype & phenotype Glutamic Acid - genetics Glutamic Acid - metabolism Humanities and Social Sciences Humans Kinases MAP Kinase Signaling System - genetics Mice multidisciplinary Myelin Sheath - genetics Myelin Sheath - metabolism Nervous system Peripheral Nerve Injuries - genetics Peripheral Nerve Injuries - pathology Peripheral Nervous System - injuries Peripheral Nervous System - metabolism Peripheral Nervous System - pathology Phosphorylation Proteins Proto-Oncogene Proteins c-akt - genetics Rats Receptor, ErbB-2 - genetics Receptors, Metabotropic Glutamate - genetics Schwann Cells - metabolism Schwann Cells - pathology Sciatic Nerve - injuries Sciatic Nerve - pathology Science
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