Interaction of strain and interleukin-1 in articular cartilage: effects on proteoglycan synthesis in chondrocytes

In temporomandibular joint disorders, the release of proinflammatory cytokines such as interleukin-1 (IL-1) initiates an inflammatory process disrupting cartilage homeostasis, ultimately leading to cartilage destruction. Additionally, mechanical stimuli affect articular chondrocyte metabolism. While...

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Veröffentlicht in:	International journal of oral and maxillofacial surgery 2000-10, Vol.29 (5), p.389-394
Hauptverfasser:	Gassner, Robert J., Buckley, Michael J., Studer, Rebecca K., Evans, Chris H., Agarwal, Sudha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals articular cartilage Biological and medical sciences Cartilage, Articular - chemistry Cartilage, Articular - physiology Cells, Cultured Chondrocytes - chemistry Chondrocytes - metabolism cytokines Dentistry Facial bones, jaws, teeth, parodontium: diseases, semeiology Humans interleukin-1 Interleukin-1 - pharmacology Interleukin-1 - physiology Investigative techniques, diagnostic techniques (general aspects) Knee Joint mechanical strain Medical sciences nitric oxide Nitric Oxide - analysis Nitric Oxide - biosynthesis Non tumoral diseases Osteoarticular system. Muscles Otorhinolaryngology. Stomatology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques proteoglycans Proteoglycans - analysis Proteoglycans - biosynthesis Rabbits Recombinant Proteins - pharmacology Shoulder Joint Stress, Mechanical temporomandibular joint Transforming Growth Factor beta - analysis
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