Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells

The endocytic protein dynamin participates in the formation of actin-based membrane protrusions such as podosomes, pseudopodia, and invadopodia, which facilitate cancer cell migration, invasion, and metastasis. However, the role of dynamin in the formation of actin-based membrane protrusions at the...

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Veröffentlicht in:	International journal of oncology 2016-09, Vol.49 (3), p.877-886
Hauptverfasser:	Yamada, Hiroshi, Takeda, Tetsuya, Michiue, Hiroyuki, Abe, Tadashi, Takei, Kohji
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Biotechnology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Care and treatment Cell adhesion & migration Cell Line, Tumor Cell Movement cortactin Cortactin - genetics Cortactin - metabolism Development and progression dynamin Dynamins - genetics Dynamins - metabolism filopodia Gene Knockdown Techniques Genetic aspects Guanosine triphosphatase Humans Immunoglobulins Innovations Lung cancer Lung cancer, Non-small cell Lung Neoplasms - genetics Lung Neoplasms - metabolism Metastasis migration Molecular targeted therapy Properties Proteins Pseudopodia - metabolism
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