Automated touch screen device for recording complex rodent behaviors
•A new hardware/software system was developed to monitor rodent behaviors.•Touch screen technology is able to record all movements with high sensitivity.•Amphetamine caused increased locomotor activity and velocity of stepping activity.•The device can be used for light–dark box tests as a measure of...
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| Veröffentlicht in: | Journal of neuroscience methods 2014-08, Vol.233, p.129-136 |
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| container_title | Journal of neuroscience methods |
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| creator | Mabrouk, O.S. Dripps, I.J. Ramani, S. Chang, C. Han, J.L. Rice, K.C. Jutkiewicz, E.M. |
| description | •A new hardware/software system was developed to monitor rodent behaviors.•Touch screen technology is able to record all movements with high sensitivity.•Amphetamine caused increased locomotor activity and velocity of stepping activity.•The device can be used for light–dark box tests as a measure of anxiety.•This novel device can accurately and rapidly characterize mouse behaviors.
Monitoring mouse behavior is a critical step in the development of modern pharmacotherapies.
Here we describe the application of a novel method that utilizes a touch display computer (tablet) and software to detect, record, and report fine motor behaviors. A consumer-grade tablet device is placed in the bottom of a specially made acrylic cage allowing the animal to walk on the device (MouseTrapp). We describe its application in open field (for general locomotor studies) which measures step lengths and velocity. The device can perform light–dark (anxiety) tests by illuminating half of the screen and keeping the other half darkened. A divider is built into the lid of the device allowing the animal free access to either side.
Treating mice with amphetamine and the delta opioid peptide receptor agonist SNC80 stimulated locomotor activity on the device. Amphetamine increased step velocity but not step length during its peak effect (40–70min after treatment), thus indicating detection of subtle amphetamine-induced effects. Animals showed a preference (74% of time spent) for the darkened half compared to the illuminated side.
Animals were videotaped within the chamber to compare quadrant crosses to detect motion on the device. The slope, duration and magnitude of quadrant crosses tightly correlated with overall locomotor activity as detected by MouseTrapp.
We suggest that modern touch display devices such as MouseTrapp will be an important step toward automation of behavioral analyses for characterizing phenotypes and drug effects. |
| doi_str_mv | 10.1016/j.jneumeth.2014.05.004 |
| format | Article |
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Monitoring mouse behavior is a critical step in the development of modern pharmacotherapies.
Here we describe the application of a novel method that utilizes a touch display computer (tablet) and software to detect, record, and report fine motor behaviors. A consumer-grade tablet device is placed in the bottom of a specially made acrylic cage allowing the animal to walk on the device (MouseTrapp). We describe its application in open field (for general locomotor studies) which measures step lengths and velocity. The device can perform light–dark (anxiety) tests by illuminating half of the screen and keeping the other half darkened. A divider is built into the lid of the device allowing the animal free access to either side.
Treating mice with amphetamine and the delta opioid peptide receptor agonist SNC80 stimulated locomotor activity on the device. Amphetamine increased step velocity but not step length during its peak effect (40–70min after treatment), thus indicating detection of subtle amphetamine-induced effects. Animals showed a preference (74% of time spent) for the darkened half compared to the illuminated side.
Animals were videotaped within the chamber to compare quadrant crosses to detect motion on the device. The slope, duration and magnitude of quadrant crosses tightly correlated with overall locomotor activity as detected by MouseTrapp.
We suggest that modern touch display devices such as MouseTrapp will be an important step toward automation of behavioral analyses for characterizing phenotypes and drug effects.</description><identifier>ISSN: 0165-0270</identifier><identifier>EISSN: 1872-678X</identifier><identifier>DOI: 10.1016/j.jneumeth.2014.05.004</identifier><identifier>PMID: 24952323</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Actigraphy - instrumentation ; Actigraphy - methods ; Amphetamine - pharmacology ; Analgesics, Opioid - pharmacology ; Animals ; Anxiety ; Anxiety - diagnosis ; Anxiety - physiopathology ; Behavior ; Behavior, Animal ; Benzamides - pharmacology ; Biomechanical Phenomena ; Central Nervous System Stimulants - pharmacology ; Female ; Light–dark box ; Male ; Mice, Inbred C57BL ; Microcomputers ; Motor Activity - drug effects ; Motor Activity - physiology ; Motor function ; Mouse ; Movement ; Open field ; Pattern Recognition, Automated - methods ; Piperazines - pharmacology ; Receptors, Opioid, delta - agonists ; Receptors, Opioid, delta - metabolism ; Software ; Technology ; Touch ; User-Computer Interface</subject><ispartof>Journal of neuroscience methods, 2014-08, Vol.233, p.129-136</ispartof><rights>2014 Elsevier B.V.</rights><rights>Copyright © 2014 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-6608af9475794e75bc39f8ba102e151488879d79295edb4ae4bda869a60c4d4d3</citedby><cites>FETCH-LOGICAL-c471t-6608af9475794e75bc39f8ba102e151488879d79295edb4ae4bda869a60c4d4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165027014001587$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24952323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mabrouk, O.S.</creatorcontrib><creatorcontrib>Dripps, I.J.</creatorcontrib><creatorcontrib>Ramani, S.</creatorcontrib><creatorcontrib>Chang, C.</creatorcontrib><creatorcontrib>Han, J.L.</creatorcontrib><creatorcontrib>Rice, K.C.</creatorcontrib><creatorcontrib>Jutkiewicz, E.M.</creatorcontrib><title>Automated touch screen device for recording complex rodent behaviors</title><title>Journal of neuroscience methods</title><addtitle>J Neurosci Methods</addtitle><description>•A new hardware/software system was developed to monitor rodent behaviors.•Touch screen technology is able to record all movements with high sensitivity.•Amphetamine caused increased locomotor activity and velocity of stepping activity.•The device can be used for light–dark box tests as a measure of anxiety.•This novel device can accurately and rapidly characterize mouse behaviors.
Monitoring mouse behavior is a critical step in the development of modern pharmacotherapies.
Here we describe the application of a novel method that utilizes a touch display computer (tablet) and software to detect, record, and report fine motor behaviors. A consumer-grade tablet device is placed in the bottom of a specially made acrylic cage allowing the animal to walk on the device (MouseTrapp). We describe its application in open field (for general locomotor studies) which measures step lengths and velocity. The device can perform light–dark (anxiety) tests by illuminating half of the screen and keeping the other half darkened. A divider is built into the lid of the device allowing the animal free access to either side.
Treating mice with amphetamine and the delta opioid peptide receptor agonist SNC80 stimulated locomotor activity on the device. Amphetamine increased step velocity but not step length during its peak effect (40–70min after treatment), thus indicating detection of subtle amphetamine-induced effects. Animals showed a preference (74% of time spent) for the darkened half compared to the illuminated side.
Animals were videotaped within the chamber to compare quadrant crosses to detect motion on the device. The slope, duration and magnitude of quadrant crosses tightly correlated with overall locomotor activity as detected by MouseTrapp.
We suggest that modern touch display devices such as MouseTrapp will be an important step toward automation of behavioral analyses for characterizing phenotypes and drug effects.</description><subject>Actigraphy - instrumentation</subject><subject>Actigraphy - methods</subject><subject>Amphetamine - pharmacology</subject><subject>Analgesics, Opioid - pharmacology</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - diagnosis</subject><subject>Anxiety - physiopathology</subject><subject>Behavior</subject><subject>Behavior, Animal</subject><subject>Benzamides - pharmacology</subject><subject>Biomechanical Phenomena</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Female</subject><subject>Light–dark box</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Microcomputers</subject><subject>Motor Activity - drug effects</subject><subject>Motor Activity - physiology</subject><subject>Motor function</subject><subject>Mouse</subject><subject>Movement</subject><subject>Open field</subject><subject>Pattern Recognition, Automated - methods</subject><subject>Piperazines - pharmacology</subject><subject>Receptors, Opioid, delta - agonists</subject><subject>Receptors, Opioid, delta - metabolism</subject><subject>Software</subject><subject>Technology</subject><subject>Touch</subject><subject>User-Computer Interface</subject><issn>0165-0270</issn><issn>1872-678X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS0EokvhK1Q5ckk69vrvBVEVKEiVuIDEzXLsSderJF7sZAXfHlfbVnDiNIf5vTej9wi5oNBRoPJy3-1nXCdcdh0DyjsQHQB_RjZUK9ZKpX88J5sKihaYgjPyqpQ9VMKAfEnOGDeCbdl2Qz5crUua3IKhWdLqd03xGXFuAh6jx2ZIucnoUw5xvmt8mg4j_mpyCjgvTY87d4wpl9fkxeDGgm8e5jn5_unjt-vP7e3Xmy_XV7et54ourZSg3WC4EspwVKL3WzPo3lFgSAXlWmtlgjLMCAw9d8j74LQ0ToLngYftOXl38j2s_YTB1yeyG-0hx8nl3za5aP_dzHFn79LRcsM1ZVAN3j4Y5PRzxbLYKRaP4-hmTGuxVHBDjTRgKipPqM-plIzD0xkK9r4Cu7ePFdj7CiwIWwOuwou_n3ySPWZegfcnAGtUx4jZFh9x9hhijXqxIcX_3fgDKt6dCA</recordid><startdate>20140815</startdate><enddate>20140815</enddate><creator>Mabrouk, O.S.</creator><creator>Dripps, I.J.</creator><creator>Ramani, S.</creator><creator>Chang, C.</creator><creator>Han, J.L.</creator><creator>Rice, K.C.</creator><creator>Jutkiewicz, E.M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140815</creationdate><title>Automated touch screen device for recording complex rodent behaviors</title><author>Mabrouk, O.S. ; Dripps, I.J. ; Ramani, S. ; Chang, C. ; Han, J.L. ; Rice, K.C. ; Jutkiewicz, E.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-6608af9475794e75bc39f8ba102e151488879d79295edb4ae4bda869a60c4d4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Actigraphy - instrumentation</topic><topic>Actigraphy - methods</topic><topic>Amphetamine - pharmacology</topic><topic>Analgesics, Opioid - pharmacology</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - diagnosis</topic><topic>Anxiety - physiopathology</topic><topic>Behavior</topic><topic>Behavior, Animal</topic><topic>Benzamides - pharmacology</topic><topic>Biomechanical Phenomena</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Female</topic><topic>Light–dark box</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>Microcomputers</topic><topic>Motor Activity - drug effects</topic><topic>Motor Activity - physiology</topic><topic>Motor function</topic><topic>Mouse</topic><topic>Movement</topic><topic>Open field</topic><topic>Pattern Recognition, Automated - methods</topic><topic>Piperazines - pharmacology</topic><topic>Receptors, Opioid, delta - agonists</topic><topic>Receptors, Opioid, delta - metabolism</topic><topic>Software</topic><topic>Technology</topic><topic>Touch</topic><topic>User-Computer Interface</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mabrouk, O.S.</creatorcontrib><creatorcontrib>Dripps, I.J.</creatorcontrib><creatorcontrib>Ramani, S.</creatorcontrib><creatorcontrib>Chang, C.</creatorcontrib><creatorcontrib>Han, J.L.</creatorcontrib><creatorcontrib>Rice, K.C.</creatorcontrib><creatorcontrib>Jutkiewicz, E.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroscience methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mabrouk, O.S.</au><au>Dripps, I.J.</au><au>Ramani, S.</au><au>Chang, C.</au><au>Han, J.L.</au><au>Rice, K.C.</au><au>Jutkiewicz, E.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Automated touch screen device for recording complex rodent behaviors</atitle><jtitle>Journal of neuroscience methods</jtitle><addtitle>J Neurosci Methods</addtitle><date>2014-08-15</date><risdate>2014</risdate><volume>233</volume><spage>129</spage><epage>136</epage><pages>129-136</pages><issn>0165-0270</issn><eissn>1872-678X</eissn><abstract>•A new hardware/software system was developed to monitor rodent behaviors.•Touch screen technology is able to record all movements with high sensitivity.•Amphetamine caused increased locomotor activity and velocity of stepping activity.•The device can be used for light–dark box tests as a measure of anxiety.•This novel device can accurately and rapidly characterize mouse behaviors.
Monitoring mouse behavior is a critical step in the development of modern pharmacotherapies.
Here we describe the application of a novel method that utilizes a touch display computer (tablet) and software to detect, record, and report fine motor behaviors. A consumer-grade tablet device is placed in the bottom of a specially made acrylic cage allowing the animal to walk on the device (MouseTrapp). We describe its application in open field (for general locomotor studies) which measures step lengths and velocity. The device can perform light–dark (anxiety) tests by illuminating half of the screen and keeping the other half darkened. A divider is built into the lid of the device allowing the animal free access to either side.
Treating mice with amphetamine and the delta opioid peptide receptor agonist SNC80 stimulated locomotor activity on the device. Amphetamine increased step velocity but not step length during its peak effect (40–70min after treatment), thus indicating detection of subtle amphetamine-induced effects. Animals showed a preference (74% of time spent) for the darkened half compared to the illuminated side.
Animals were videotaped within the chamber to compare quadrant crosses to detect motion on the device. The slope, duration and magnitude of quadrant crosses tightly correlated with overall locomotor activity as detected by MouseTrapp.
We suggest that modern touch display devices such as MouseTrapp will be an important step toward automation of behavioral analyses for characterizing phenotypes and drug effects.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24952323</pmid><doi>10.1016/j.jneumeth.2014.05.004</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neuroscience methods, 2014-08, Vol.233, p.129-136 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Actigraphy - instrumentation Actigraphy - methods Amphetamine - pharmacology Analgesics, Opioid - pharmacology Animals Anxiety Anxiety - diagnosis Anxiety - physiopathology Behavior Behavior, Animal Benzamides - pharmacology Biomechanical Phenomena Central Nervous System Stimulants - pharmacology Female Light–dark box Male Mice, Inbred C57BL Microcomputers Motor Activity - drug effects Motor Activity - physiology Motor function Mouse Movement Open field Pattern Recognition, Automated - methods Piperazines - pharmacology Receptors, Opioid, delta - agonists Receptors, Opioid, delta - metabolism Software Technology Touch User-Computer Interface |
| title | Automated touch screen device for recording complex rodent behaviors |
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