Histone deacetylase inhibition reveals a tumor-suppressive function of MYC-regulated miRNA in breast and lung carcinoma

Histone deacetylase (HDAC) inhibition leads to dynamic changes in the epigenetic landscape that is postulated to alter the expression of critical mediators of cellular proliferation and death. While current HDAC inhibitors have shown to be efficacious in the treatment of specific hematologic maligna...

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Veröffentlicht in:	Cell death and differentiation 2016-08, Vol.23 (8), p.1312-1321
Hauptverfasser:	Adams, C M, Eischen, C M
Format:	Artikel
Sprache:	eng
Schlagworte:	13 3' Untranslated Regions 38 631/67/395 692/699/67 A549 Cells Apoptosis Apoptosis - drug effects Base Sequence bcl-X Protein - antagonists & inhibitors bcl-X Protein - genetics bcl-X Protein - metabolism Binding Sites Biochemistry Biomedical and Life Sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Biology Cell Cycle Analysis Cell death Cell Line, Tumor Chromatin Immunoprecipitation Female Gene expression Histone Deacetylase Inhibitors - pharmacology Humans Immunology Life Sciences Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphoma MicroRNAs MicroRNAs - metabolism Original Paper Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-myc - metabolism RNA polymerase Sequence Alignment Stem Cells Up-Regulation - drug effects
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