The balance between Foxp3 and Ror-γt expression in peripheral blood is altered by tocilizumab and abatacept in patients with rheumatoid arthritis

The balance between Th17 cells and regulatory T (Treg) cells has been shown to play an important role in the development of rheumatoid arthritis (RA). Recent studies have shown that treatment with abatacept (ABT) or tocilizumab (TCZ) affects Th17 and Treg cell populations. Although not unanimously a...

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Veröffentlicht in:	BMC musculoskeletal disorders 2016-07, Vol.17 (1), p.290-290, Article 290
Hauptverfasser:	Tada, Yoshifumi, Ono, Nobuyuki, Suematsu, Rie, Tashiro, Satoko, Sadanaga, Yuri, Tokuda, Yukiko, Ono, Yukihide, Nakao, Yoshinobu, Maruyama, Akihito, Ohta, Akihide, Koarada, Syuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept - pharmacology Abatacept - therapeutic use Adult Aged Antibodies, Monoclonal, Humanized - pharmacology Antibodies, Monoclonal, Humanized - therapeutic use Antirheumatic Agents - pharmacology Antirheumatic Agents - therapeutic use Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - drug therapy Female Forkhead Transcription Factors - metabolism GATA3 Transcription Factor - metabolism Humans Male Middle Aged Nuclear Receptor Subfamily 1, Group F, Member 3 - metabolism Reverse Transcriptase Polymerase Chain Reaction T-Box Domain Proteins - metabolism T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism Th17 Cells - drug effects Th17 Cells - metabolism
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