MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions

Our previous studies have shown that Dexamethasone (Dex) reduced the expression of matrix‐metalloproteinases (MMPs ‐1,‐3,‐9,‐13), IL‐1β and IL‐6, while it significantly increased MMP‐8 mRNA transcripts in a concomitant dry eye and corneal alkali burn murine model (CM). To investigate if MMP‐8 induct...

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Veröffentlicht in:	Journal of cellular physiology 2016-11, Vol.231 (11), p.2506-2516
Hauptverfasser:	Bian, Fang, Wang, Changjun, Tukler-Henriksson, Johanna, Pflugfelder, Stephen C., Camodeca, Caterina, Nuti, Elisa, Rossello, Armando, Li, De-Quan, de Paiva, Cintia S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkalies Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Burns, Chemical - complications Burns, Chemical - drug therapy Burns, Chemical - enzymology Cornea - enzymology Cornea - pathology Desiccation Dexamethasone - pharmacology Dexamethasone - therapeutic use Disease Models, Animal Dry Eye Syndromes - complications Dry Eye Syndromes - enzymology Eye Burns - complications Eye Burns - drug therapy Eye Burns - enzymology Female Matrix Metalloproteinase 8 - deficiency Matrix Metalloproteinase 8 - genetics Matrix Metalloproteinase 8 - metabolism Matrix Metalloproteinase Inhibitors - pharmacology Matrix Metalloproteinase Inhibitors - therapeutic use Mice, Inbred C57BL Mice, Knockout Neutrophil Infiltration - drug effects Neutrophils - drug effects Neutrophils - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Stress, Physiological
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