Toll-like receptor 4 contributes to chronic itch, alloknesis, and spinal astrocyte activation in male mice

Increasing evidence suggests that Toll-like receptor 4 (TLR4) contributes importantly to spinal cord glial activation and chronic pain sensitization; however, its unique role in acute and chronic itch is unclear. In this study, we investigated the involvement of TLR4 in acute and chronic itch models...

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Veröffentlicht in:	Pain (Amsterdam) 2016-04, Vol.157 (4), p.806-817
Hauptverfasser:	Liu, Tong, Han, Qingjian, Chen, Gang, Huang, Ya, Zhao, Lin-Xia, Berta, Temugin, Gao, Yong-Jing, Ji, Ru-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - immunology Astrocytes - metabolism Chronic Disease Disease Models, Animal Hyperalgesia - chemically induced Male Mice, Knockout Posterior Horn Cells - physiology Pruritus - chemically induced Pruritus - metabolism Spinal Cord Dorsal Horn - immunology Spinal Cord Dorsal Horn - metabolism Toll-Like Receptor 4 - deficiency Toll-Like Receptor 4 - metabolism
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