Antiretroviral therapy in HIV‐1‐infected individuals with CD4 count below 100 cells/mm3 results in differential recovery of monocyte activation

In advanced HIV‐1 disease, 24 weeks of ART‐mediated recovery results in reversal of activated cell‐specific monocyte subsets, with minimal recovery of soluble makers of tissue‐associated myeloid activation. Reversal of monocyte and macrophage activation and the relationship to viral suppression and...

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Veröffentlicht in:	Journal of leukocyte biology 2016-07, Vol.100 (1), p.223-231
Hauptverfasser:	Patro, Sean C., Azzoni, Livio, Joseph, Jocelin, Fair, Matthew G., Sierra‐Madero, Juan G., Rassool, Mohammed S., Sanne, Ian, Montaner, Luis J.
Format:	Artikel
Sprache:	eng
Schlagworte:	activation resolution Adult AIDS Antiretroviral Therapy, Highly Active Biomarkers - metabolism CCR5 Receptor Antagonists - pharmacology CD4 Lymphocyte Count Cyclohexanes - pharmacology Female HIV Infections - drug therapy HIV Infections - immunology HIV Infections - metabolism HIV Infections - virology HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - virology Lymphocyte Activation macrophage Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Macrophages - virology Male Middle Aged Monocytes - drug effects Monocytes - immunology Monocytes - metabolism Monocytes - virology pathogenesis Translational & Clinical Immunology Triazoles - pharmacology Viral Load - drug effects Viral Load - immunology
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