Lysophosphatidic acid does not cause blood/lymphatic vessel plasticity in the rat mesentery culture model

Understanding the mechanisms behind endothelial cell identity is crucial for the goal of manipulating microvascular networks. Lysophosphatidic acid (LPA) and serum stimulation have been suggested to induce a lymphatic identity in blood endothelial cells in vitro. The objective of this study was to d...

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Veröffentlicht in:	Physiological reports 2016-07, Vol.4 (13), p.e12857-n/a
Hauptverfasser:	Sweat, Richard S., Azimi, Mohammad S., Suarez‐Martinez, Ariana D., Katakam, Prasad, Murfee, Walter L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Biomarkers - metabolism Blood vessels Cell adhesion & migration Cell culture Cell growth Cell Plasticity - drug effects Cellular Physiology endothelial cell Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Homeodomain Proteins - metabolism lymphangiogenesis Lymphangiogenesis - drug effects lymphatic Lymphatic system Lymphatic Vessels - drug effects Lymphatic Vessels - metabolism Lysophosphatidic acid Lysophospholipids - pharmacology Male Mesentery Mesentery - blood supply Microcirculation Microvasculature Microvessels - drug effects Microvessels - metabolism Neovascularization, Physiologic - drug effects Original Research Phenotype Physiology Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Rats, Wistar Receptors, Cell Surface - metabolism Studies Time Factors Tissue Culture Techniques Tumor Suppressor Proteins - metabolism Vascular endothelial growth factor Vasculature
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