Clinical neurocardiology defining the value of neuroscience‐based cardiovascular therapeutics
The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience‐based cardiovascular therapeutics is increasingly evident. This White Paper reviews the...
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| Veröffentlicht in: | The Journal of physiology 2016-07, Vol.594 (14), p.3911-3954 |
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| container_end_page | 3954 |
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| container_issue | 14 |
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| container_title | The Journal of physiology |
| container_volume | 594 |
| creator | Shivkumar, Kalyanam Ajijola, Olujimi A. Anand, Inder Armour, J. Andrew Chen, Peng‐Sheng Esler, Murray Ferrari, Gaetano M. Fishbein, Michael C. Goldberger, Jeffrey J. Harper, Ronald M. Joyner, Michael J. Khalsa, Sahib S. Kumar, Rajesh Lane, Richard Mahajan, Aman Po, Sunny Schwartz, Peter J. Somers, Virend K. Valderrabano, Miguel Vaseghi, Marmar Zipes, Douglas P. |
| description | The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience‐based cardiovascular therapeutics is increasingly evident. This White Paper reviews the current state of understanding of human cardiac neuroanatomy, neurophysiology, pathophysiology in specific disease conditions, autonomic testing, risk stratification, and neuromodulatory strategies to mitigate the progression of cardiovascular diseases. |
| doi_str_mv | 10.1113/JP271870 |
| format | Article |
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Andrew ; Chen, Peng‐Sheng ; Esler, Murray ; Ferrari, Gaetano M. ; Fishbein, Michael C. ; Goldberger, Jeffrey J. ; Harper, Ronald M. ; Joyner, Michael J. ; Khalsa, Sahib S. ; Kumar, Rajesh ; Lane, Richard ; Mahajan, Aman ; Po, Sunny ; Schwartz, Peter J. ; Somers, Virend K. ; Valderrabano, Miguel ; Vaseghi, Marmar ; Zipes, Douglas P.</creator><creatorcontrib>Shivkumar, Kalyanam ; Ajijola, Olujimi A. ; Anand, Inder ; Armour, J. Andrew ; Chen, Peng‐Sheng ; Esler, Murray ; Ferrari, Gaetano M. ; Fishbein, Michael C. ; Goldberger, Jeffrey J. ; Harper, Ronald M. ; Joyner, Michael J. ; Khalsa, Sahib S. ; Kumar, Rajesh ; Lane, Richard ; Mahajan, Aman ; Po, Sunny ; Schwartz, Peter J. ; Somers, Virend K. ; Valderrabano, Miguel ; Vaseghi, Marmar ; Zipes, Douglas P.</creatorcontrib><description>The autonomic nervous system regulates all aspects of normal cardiac function, and is recognized to play a critical role in the pathophysiology of many cardiovascular diseases. As such, the value of neuroscience‐based cardiovascular therapeutics is increasingly evident. 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The Journal of Physiology © 2016 The Physiological Society</rights><rights>2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.</rights><rights>Journal compilation © 2016 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6462-ee731fb623bdca72001ab6dbf4bb82b2898a5a11464b5bc45874f157d2697fb53</citedby><cites>FETCH-LOGICAL-c6462-ee731fb623bdca72001ab6dbf4bb82b2898a5a11464b5bc45874f157d2697fb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945719/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4945719/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27114333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shivkumar, Kalyanam</creatorcontrib><creatorcontrib>Ajijola, Olujimi A.</creatorcontrib><creatorcontrib>Anand, Inder</creatorcontrib><creatorcontrib>Armour, J. 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As such, the value of neuroscience‐based cardiovascular therapeutics is increasingly evident. 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Andrew ; Chen, Peng‐Sheng ; Esler, Murray ; Ferrari, Gaetano M. ; Fishbein, Michael C. ; Goldberger, Jeffrey J. ; Harper, Ronald M. ; Joyner, Michael J. ; Khalsa, Sahib S. ; Kumar, Rajesh ; Lane, Richard ; Mahajan, Aman ; Po, Sunny ; Schwartz, Peter J. ; Somers, Virend K. ; Valderrabano, Miguel ; Vaseghi, Marmar ; Zipes, Douglas P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6462-ee731fb623bdca72001ab6dbf4bb82b2898a5a11464b5bc45874f157d2697fb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Autonomic Nervous System - physiology</topic><topic>Cardiovascular Conditions, Disorders and Treatments</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Cardiovascular Diseases - therapy</topic><topic>Cardiovascular Physiology</topic><topic>Heart - innervation</topic><topic>Heart - physiology</topic><topic>Heart - physiopathology</topic><topic>Humans</topic><topic>Neuroscience</topic><topic>Neurosciences</topic><topic>Special section reviews: Cardiac autonomic control in health and disease</topic><topic>White Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shivkumar, Kalyanam</creatorcontrib><creatorcontrib>Ajijola, Olujimi A.</creatorcontrib><creatorcontrib>Anand, Inder</creatorcontrib><creatorcontrib>Armour, J. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Online Library Free Content; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Autonomic Nervous System - physiology Cardiovascular Conditions, Disorders and Treatments Cardiovascular Diseases - physiopathology Cardiovascular Diseases - therapy Cardiovascular Physiology Heart - innervation Heart - physiology Heart - physiopathology Humans Neuroscience Neurosciences Special section reviews: Cardiac autonomic control in health and disease White Paper |
| title | Clinical neurocardiology defining the value of neuroscience‐based cardiovascular therapeutics |
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