A CRISPR screen defines a signal peptide processing pathway required by flaviviruses

Components of the endoplasmic-reticulum-associated signal peptidase complex is required for infection by numerous flaviviruses, including West Nile, dengue and Zika viruses, but is not required for infection by other types of virus or for host protein synthesis. Flaviviruses infect hundreds of milli...

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Veröffentlicht in:	Nature (London) 2016-07, Vol.535 (7610), p.164-168
Hauptverfasser:	Zhang, Rong, Miner, Jonathan J., Gorman, Matthew J., Rausch, Keiko, Ramage, Holly, White, James P., Zuiani, Adam, Zhang, Ping, Fernandez, Estefania, Zhang, Qiang, Dowd, Kimberly A., Pierson, Theodore C., Cherry, Sara, Diamond, Michael S.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/31 13/89 38 38/23 38/47 49/109 49/40 631/326/421 631/326/596/1413 631/326/596/1879 631/326/596/2557 692/420/254 Animals Apoptosis Biodegradation Cell Line CRISPR-Cas Systems - genetics Drosophila - cytology Drosophila - genetics Drosophila - virology Drug Discovery Endoplasmic reticulum Endoplasmic Reticulum - metabolism Female Flavivirus - metabolism Flavivirus - physiology Flavivirus Infections - genetics Flavivirus Infections - virology Gene expression Genetic engineering Genome, Human - genetics Glycosylation Health aspects Host-Derived Cellular Factors - genetics Host-Pathogen Interactions - genetics Host-virus relationships Humanities and Social Sciences Humans Infections letter Membrane Proteins - genetics Molecular Targeted Therapy multidisciplinary Observations Peptides Protein Sorting Signals - physiology Protein Transport - genetics Proteins Proteolysis Reproducibility of Results Science Serine Endopeptidases - genetics Species Specificity Translocation Vector-borne diseases Viral Proteins - chemistry Viral Proteins - metabolism Viral Structural Proteins - metabolism Viruses
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