Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV

The crystal structure of the GP1–GP2 complex of the prototypical arenavirus LCMV in prefusion form sheds light on the conformational changes that the arenavirus glycoprotein undergoes to cause fusion. Arenaviruses exist worldwide and can cause hemorrhagic fever and neurologic disease. A single glyco...

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Veröffentlicht in:	Nature structural & molecular biology 2016-06, Vol.23 (6), p.513-521
Hauptverfasser:	Hastie, Kathryn M, Igonet, Sébastien, Sullivan, Brian M, Legrand, Pierre, Zandonatti, Michelle A, Robinson, James E, Garry, Robert F, Rey, Félix A, Oldstone, Michael B, Saphire, Erica Ollmann
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/31 631/326/596/2116 631/535/1266 82/16 82/80 82/83 Animals Arenavirus Arenaviruses Biochemistry Biological Microscopy Cell Line Crystal structure Crystallography, X-Ray Crystals Drosophila Genetic aspects Glycoproteins Glycosylation Health aspects Humans Life Sciences Lymphocytic Choriomeningitis - metabolism Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus - chemistry Lymphocytic choriomeningitis virus - physiology Membrane Biology Membrane Glycoproteins - chemistry Membrane Glycoproteins - metabolism Models, Molecular Properties Protein Conformation Protein expression Protein Multimerization Protein Sorting Signals Protein Structure Protein Subunits - chemistry Protein Subunits - metabolism Structure Vaccines Viral Envelope Proteins - chemistry Viral Envelope Proteins - metabolism Virulence (Microbiology) Virus Internalization Viruses
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