Identification of Redox and Glucose-Dependent Txnip Protein Interactions

Thioredoxin-interacting protein (Txnip) acts as a negative regulator of thioredoxin function and is a critical modulator of several diseases including, but not limited to, diabetes, ischemia-reperfusion cardiac injury, and carcinogenesis. Therefore, Txnip has become an attractive therapeutic target...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-10
Hauptverfasser:	Vitiello, Peter F., Motamedchaboki, Khatereh, Amolins, Michael W., Kim, Dae In, Neuharth, Skyla, Forred, Benjamin J., Roux, Kyle J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Carrier Proteins - metabolism Crystal structure Cyclin-dependent kinases Cysteine Dextrose Diabetes Fatty acids Fibroblasts Gene expression Glucose Glucose - pharmacology Glucose metabolism Health aspects HEK293 Cells Homeostasis Humans Inflammation Ischemia Kinases Metabolism Mutation Oxidation-Reduction - drug effects Protein Binding - drug effects Protein Interaction Mapping Proteins Rodents Thioredoxin
Online-Zugang:	Volltext
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