PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1

Cytosolic RNA sensing is a prerequisite for initiation of innate immune response against RNA viral pathogens. Signaling through RIG-I (retinoic acid-inducible gene I)-like receptors (RLRs) to TBK1 (Tank-binding kinase 1)/IKKε (IκB kinase ε) kinases is transduced by mitochondria-associated MAVS (mito...

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Veröffentlicht in:	Science advances 2016-07, Vol.2 (7), p.e1501889-e1501889
Hauptverfasser:	Xiang, Weiwen, Zhang, Qian, Lin, Xia, Wu, Shiying, Zhou, Yao, Meng, Fansen, Fan, Yunyun, Shen, Tao, Xiao, Mu, Xia, Zongping, Zou, Jian, Feng, Xin-Hua, Xu, Pinglong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Animals, Genetically Modified - metabolism Cell Line CRISPR-Cas Systems - genetics Cytosol - metabolism Embryo, Nonmammalian - metabolism Embryo, Nonmammalian - virology HEK293 Cells Humans I-kappa B Kinase - metabolism Interferon Regulatory Factor-3 - genetics Interferon Regulatory Factor-3 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Models, Animal Protein Phosphatase 2C - antagonists & inhibitors Protein Phosphatase 2C - genetics Protein Phosphatase 2C - metabolism Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA - metabolism RNA Interference RNA, Small Interfering - metabolism SciAdv r-articles Sendai virus - drug effects Sendai virus - pathogenicity Sendai virus - physiology Vesiculovirus - drug effects Vesiculovirus - pathogenicity Vesiculovirus - physiology Virology Zebrafish - growth & development Zebrafish - metabolism
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