Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing

Phosphorylation has been generally thought to activate the SR family of splicing factors for efficient splice-site recognition, but this idea is incompatible with an early observation that overexpression of an SR protein kinase, such as the CDC2-like kinase 1 (CLK1), weakens splice-site selection. H...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cell 2016-07, Vol.63 (2), p.218-228
Hauptverfasser:	Aubol, Brandon E., Wu, Guowei, Keshwani, Malik M., Movassat, Maliheh, Fattet, Laurent, Hertel, Klemens J., Fu, Xiang-Dong, Adams, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Globins - genetics beta-Globins - metabolism Catalysis HeLa Cells Humans Phosphorylation Protein Binding Protein Interaction Domains and Motifs Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Ribonucleoprotein, U1 Small Nuclear - metabolism RNA Interference RNA Precursors - genetics RNA Precursors - metabolism RNA Splicing RNA, Messenger - genetics RNA, Messenger - metabolism Spliceosomes - enzymology Spliceosomes - genetics Time Factors Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!