Response of patients with postencephalitic Parkinsonism to levodopa
Thirty patients with postencephalitic Parkinsonism were treated with levodopa. In seven patients, treatment was withdrawn because of adverse reactions or insufficient benefit. Improvements observed in 26 patients who remained on treatment for a sufficient period to permit adequate assessment were co...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1972-08, Vol.35 (4), p.487-495 |
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| container_end_page | 495 |
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| container_issue | 4 |
| container_start_page | 487 |
| container_title | Journal of neurology, neurosurgery and psychiatry |
| container_volume | 35 |
| creator | Duvoisin, Roger C. Lobo-Antunes, Joao Yahr, Melvin D. |
| description | Thirty patients with postencephalitic Parkinsonism were treated with levodopa. In seven patients, treatment was withdrawn because of adverse reactions or insufficient benefit. Improvements observed in 26 patients who remained on treatment for a sufficient period to permit adequate assessment were comparable with those previously reported in Parkinson's disease. Some sequelae of encephalitis lethargica—notably, oculogyria and drooling—were appreciably improved in most patients affected, whereas choreoathetoid dyskinesias were aggravated by levodopa. Adventitious choreiform involuntary movements and behaviour disorders were the major side-effects. Patients with postencephalitic Parkinsonism may respond as well as patients with Parkinson's disease to levodopa but they develop both favourable responses and side-effects at a lower dosage and require careful dosage adjustments and close surveillance. |
| doi_str_mv | 10.1136/jnnp.35.4.487 |
| format | Article |
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Patients with postencephalitic Parkinsonism may respond as well as patients with Parkinson's disease to levodopa but they develop both favourable responses and side-effects at a lower dosage and require careful dosage adjustments and close surveillance.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.35.4.487</identifier><identifier>PMID: 5049808</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Aged ; Dihydroxyphenylalanine - administration & dosage ; Dihydroxyphenylalanine - adverse effects ; Dihydroxyphenylalanine - therapeutic use ; Encephalitis - drug therapy ; Evaluation Studies as Topic ; Female ; Humans ; Hypotension, Orthostatic - drug therapy ; Male ; Middle Aged ; Movement Disorders - drug therapy ; Parkinson Disease, Postencephalitic - drug therapy ; Social Behavior Disorders - chemically induced</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 1972-08, Vol.35 (4), p.487-495</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-11bc8eb7d9599e851964d077a62d880a86309eecc4550d67e845697e56713d6c3</citedby><cites>FETCH-LOGICAL-c419t-11bc8eb7d9599e851964d077a62d880a86309eecc4550d67e845697e56713d6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC494109/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC494109/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5049808$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duvoisin, Roger C.</creatorcontrib><creatorcontrib>Lobo-Antunes, Joao</creatorcontrib><creatorcontrib>Yahr, Melvin D.</creatorcontrib><title>Response of patients with postencephalitic Parkinsonism to levodopa</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Thirty patients with postencephalitic Parkinsonism were treated with levodopa. In seven patients, treatment was withdrawn because of adverse reactions or insufficient benefit. Improvements observed in 26 patients who remained on treatment for a sufficient period to permit adequate assessment were comparable with those previously reported in Parkinson's disease. Some sequelae of encephalitis lethargica—notably, oculogyria and drooling—were appreciably improved in most patients affected, whereas choreoathetoid dyskinesias were aggravated by levodopa. Adventitious choreiform involuntary movements and behaviour disorders were the major side-effects. Patients with postencephalitic Parkinsonism may respond as well as patients with Parkinson's disease to levodopa but they develop both favourable responses and side-effects at a lower dosage and require careful dosage adjustments and close surveillance.</description><subject>Aged</subject><subject>Dihydroxyphenylalanine - administration & dosage</subject><subject>Dihydroxyphenylalanine - adverse effects</subject><subject>Dihydroxyphenylalanine - therapeutic use</subject><subject>Encephalitis - drug therapy</subject><subject>Evaluation Studies as Topic</subject><subject>Female</subject><subject>Humans</subject><subject>Hypotension, Orthostatic - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Movement Disorders - drug therapy</subject><subject>Parkinson Disease, Postencephalitic - drug therapy</subject><subject>Social Behavior Disorders - chemically induced</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtOAjEUhhujQUSXLk3mBWZs6X3hwkwUJUSJojFumtIpUhymzXREfXuHQFDP5iz-yzn5ADhFMEMIs_NFVYUM04xkRPA90EWEiRRj-LIPuhD2-ymGFB6CoxgXcD1CdkCHQiIFFF2QP9gYfBVt4mdJ0I2zVROTT9fMk-BjYytjw1yXrnEmGev63VXRVy4uk8YnpV35wgd9DA5muoz2ZLt74On6apLfpKP7wW1-OUoNQbJJEZoaYae8kFRKKyiSjBSQc836hRBQC4ahtNYYQiksGLeCUCa5pYwjXDCDe-Bi0xs-pktbmPbVWpcq1G6p62_ltVP_lcrN1ZtfKSIJgrLNp5u8qX2MtZ3togiqNUu1ZqkwVUS1LFv_2d97O_cW3m-fa0F97eSWkmIcc6runnM1nAwH4_4jVq_4B99AgYM</recordid><startdate>19720801</startdate><enddate>19720801</enddate><creator>Duvoisin, Roger C.</creator><creator>Lobo-Antunes, Joao</creator><creator>Yahr, Melvin D.</creator><general>BMJ Publishing Group Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>19720801</creationdate><title>Response of patients with postencephalitic Parkinsonism to levodopa</title><author>Duvoisin, Roger C. ; Lobo-Antunes, Joao ; Yahr, Melvin D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-11bc8eb7d9599e851964d077a62d880a86309eecc4550d67e845697e56713d6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Aged</topic><topic>Dihydroxyphenylalanine - administration & dosage</topic><topic>Dihydroxyphenylalanine - adverse effects</topic><topic>Dihydroxyphenylalanine - therapeutic use</topic><topic>Encephalitis - drug therapy</topic><topic>Evaluation Studies as Topic</topic><topic>Female</topic><topic>Humans</topic><topic>Hypotension, Orthostatic - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Movement Disorders - drug therapy</topic><topic>Parkinson Disease, Postencephalitic - drug therapy</topic><topic>Social Behavior Disorders - chemically induced</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duvoisin, Roger C.</creatorcontrib><creatorcontrib>Lobo-Antunes, Joao</creatorcontrib><creatorcontrib>Yahr, Melvin D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duvoisin, Roger C.</au><au>Lobo-Antunes, Joao</au><au>Yahr, Melvin D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Response of patients with postencephalitic Parkinsonism to levodopa</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>1972-08-01</date><risdate>1972</risdate><volume>35</volume><issue>4</issue><spage>487</spage><epage>495</epage><pages>487-495</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><abstract>Thirty patients with postencephalitic Parkinsonism were treated with levodopa. In seven patients, treatment was withdrawn because of adverse reactions or insufficient benefit. Improvements observed in 26 patients who remained on treatment for a sufficient period to permit adequate assessment were comparable with those previously reported in Parkinson's disease. Some sequelae of encephalitis lethargica—notably, oculogyria and drooling—were appreciably improved in most patients affected, whereas choreoathetoid dyskinesias were aggravated by levodopa. Adventitious choreiform involuntary movements and behaviour disorders were the major side-effects. Patients with postencephalitic Parkinsonism may respond as well as patients with Parkinson's disease to levodopa but they develop both favourable responses and side-effects at a lower dosage and require careful dosage adjustments and close surveillance.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>5049808</pmid><doi>10.1136/jnnp.35.4.487</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of neurology, neurosurgery and psychiatry, 1972-08, Vol.35 (4), p.487-495 |
| issn | 0022-3050 1468-330X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Aged Dihydroxyphenylalanine - administration & dosage Dihydroxyphenylalanine - adverse effects Dihydroxyphenylalanine - therapeutic use Encephalitis - drug therapy Evaluation Studies as Topic Female Humans Hypotension, Orthostatic - drug therapy Male Middle Aged Movement Disorders - drug therapy Parkinson Disease, Postencephalitic - drug therapy Social Behavior Disorders - chemically induced |
| title | Response of patients with postencephalitic Parkinsonism to levodopa |
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