Efficient production of pronuclear embryos in breeding and nonbreeding season for generating transgenic sheep overexpressing TLR4

Background： Brucella is a zoonotic Gram-negative pathogen that causes abortion and infertility in ruminants and humans. TLR4 is the receptor for LPS which can recognize Brucella and initiate antigen-presenting cell activities that affect both innate and adaptive immunity. Consequently, transgenic sh...

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Veröffentlicht in:	Journal of Animal Science and Biotechnology 2016-07, Vol.8 (1), p.43-50, Article 38
Hauptverfasser:	Li, Yan, Lian, Di, Deng, Shoulong, Zhang, Xiaosheng, Zhang, Jinlong, Li, Wenting, Bai, Hai, Wang, Zhixian, Wu, Hongping, Fu, Juncai, Han, Hongbing, Feng, Jianzhong, Liu, Guoshi, Lian, Ling, Lian, Zhengxing
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive immunity adverse effects Bacteria Blood breeding season Brucella brucellosis embryo transfer Embryonic development Embryos ewes Food contamination & poisoning Gene expression gene overexpression Genes Genetic aspects growth performance Hemoglobin humans lambs Laparotomy Neutrophils Observations pathogens Pharmaceuticals Physiological aspects Physiology Seasons Sheep Southern blotting superovulation Toll-like receptor 4 Toll-like receptors Transgenic animals Variance analysis
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