Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

A neuro-inflammatory response is evident in Alzheimer's disease (AD), yet the precise mechanisms by which neuro-inflammation influences the progression of Alzheimer's disease (AD) remain poorly understood. Type-1 interferons (IFNs) are master regulators of innate immunity and have been imp...

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Veröffentlicht in:	Acta neuropathologica communications 2016-07, Vol.4 (1), p.72-72, Article 72
Hauptverfasser:	Minter, Myles R, Moore, Zachery, Zhang, Moses, Brody, Kate M, Jones, Nigel C, Shultz, Sandy R, Taylor, Juliet M, Crack, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - immunology Alzheimer Disease - pathology Alzheimer Disease - psychology Amyloid beta-Peptides - metabolism Animals Cells, Cultured Cerebral Cortex - immunology Cerebral Cortex - pathology Cognition - physiology Disease Models, Animal Female Gliosis - immunology Gliosis - pathology Gliosis - psychology Hippocampus - immunology Hippocampus - pathology Humans Male Maze Learning - physiology Mice Mice, Inbred C57BL Mice, Transgenic Neuroglia - immunology Neuroglia - pathology Neurons - immunology Neurons - pathology Peptide Fragments - metabolism Plaque, Amyloid - immunology Plaque, Amyloid - pathology Plaque, Amyloid - psychology Receptor, Interferon alpha-beta - deficiency Receptor, Interferon alpha-beta - genetics Spatial Memory - physiology
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