Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen Peroxide

Diabetes mellitus (DM) and pancreatic cancer are intimately related, as approximately 85% of patients diagnosed with pancreatic cancer have impaired glucose tolerance or even DM. Our previous studies have indicated that high glucose could promote the invasive and migratory abilities of pancreatic ca...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2016-01, Vol.2016 (2016), p.1-9
Hauptverfasser:	Zong, Liang, Jiang, Zhengdong, Chen, Xin, Zhang, Lun, Li, Wei, Ma, Qingyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Catalase - pharmacology Cell adhesion & migration Cell growth Cell Line, Tumor Cell Proliferation Development and progression Dextrose Diabetes Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - complications Epithelial-Mesenchymal Transition Free Radical Scavengers - pharmacology Glucose Health aspects Humans Hydrogen peroxide Hydrogen Peroxide - blood Hyperglycemia Hypotheses Liver Liver cancer Liver Neoplasms - blood Liver Neoplasms - secondary Medical prognosis Metastasis Mice, Inbred BALB C Mice, Nude Morphology Motility Pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - complications Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Peritoneal dialysis Polyethylene glycol Polyethylene Glycols - pharmacology Signal Transduction Stem cells Streptozocin Studies Time Factors Tumor Burden Xenograft Model Antitumor Assays
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