Bioartificial Therapy of Sepsis: Changes of Norepinephrine-Dosage in Patients and Influence on Dynamic and Cell Based Liver Tests during Extracorporeal Treatments

Purpose. Granulocyte transfusions have been used to treat immune cell dysfunction in sepsis. A granulocyte bioreactor for the extracorporeal treatment of sepsis was tested in a prospective clinical study focusing on the dosage of norepinephrine in patients and influence on dynamic and cell based liv...

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Veröffentlicht in:	BioMed research international 2016-01, Vol.2016 (2016), p.1-11
Hauptverfasser:	Ehler, Johannes, Doss, Sandra, Koch, Stephanie, Richter, Georg, Nöldge-Schomburg, Gabriele, Mitzner, Steffen R., Thomsen, Maren, Mencke, Thomas, Doß, Fanny, Wild, Thomas, Pertschy, Annette, Haubner, Cristof, Altrichter, Jens, Sauer, Martin, Henschel, Jörg
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Analysis Biomarkers - metabolism Blood & organ donations Cell Count Clinical Study Cohort Studies Cytochrome P-450 CYP1A2 Cytokines - metabolism Departments Dose-Response Relationship, Drug Drug dosages Extracorporeal Circulation - methods Granulocytes Hemodynamics Hep G2 Cells HIV Human immunodeficiency virus Humans Infection Inflammation - pathology Intensive care L-Lactate Dehydrogenase - metabolism Liver Liver - pathology Liver Function Tests Liver, Artificial Male Medical prognosis Middle Aged Mortality Noradrenaline Norepinephrine - administration & dosage Norepinephrine - therapeutic use Physiology Plasma Sepsis Sepsis - pathology Sepsis - therapy Studies Survival Analysis Treatment Outcome Tumor necrosis factor-TNF
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